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5G6I

Structure of Bacillus subtilis Nitric Oxide Synthase I218V in complex with 7-((3-(Methylamino)methyl)phenoxy)methyl)quinolin-2-amine

Functional Information from GO Data
ChainGOidnamespacecontents
A0004517molecular_functionnitric-oxide synthase activity
A0005575cellular_componentcellular_component
A0006809biological_processnitric oxide biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0020037molecular_functionheme binding
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE HEM A 901
ChainResidue
ATRP60
ATRP329
ATYR355
ATYR357
AH4B902
AM85904
AHOH2245
AHOH2246
AHOH2247
AHOH2248
AARG65
ACYS66
APHE235
AASN236
AGLY237
ATRP238
AMET240
AGLU243

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE H4B A 902
ChainResidue
AARG247
ATRP327
ATHR328
ATRP329
APHE342
AHIS343
AARG344
AHEM901
AHOH2153
AHOH2247

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 903
ChainResidue
AGLN129
ATYR239
AASN248

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE M85 A 904
ChainResidue
AHIS128
AVAL218
AASP220
APHE235
ATRP238
ATYR239
AGLU243
AHEM901
AHOH2037

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 905
ChainResidue
AARG142
AASP166
AARG254
ATYR255
ALYS257
AHOH2161
AHOH2166

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL A 906
ChainResidue
AGLU156
AGLY159
ATRP160
ATRP238
ASER298
AILE299
AHOH2099
AHOH2205

Functional Information from PROSITE/UniProt
site_idPS60001
Number of Residues8
DetailsNOS Nitric oxide synthase (NOS) signature. RCIGRLfW
ChainResidueDetails
AARG65-TRP72

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: axial binding residue
ChainResidueDetails
ACYS66

226707

PDB entries from 2024-10-30

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