Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 1918 |
| Chain | Residue |
| A | HIS673 |
| A | HIS709 |
| A | ASP710 |
| A | ASP822 |
| A | HOH2073 |
| A | HOH2095 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 1919 |
| Chain | Residue |
| A | HOH2095 |
| A | HOH2096 |
| A | HOH2121 |
| A | ASP710 |
| A | HOH2071 |
| A | HOH2094 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI A 1920 |
| Chain | Residue |
| A | ASP712 |
| A | MET714 |
| A | TYR721 |
| A | LEU728 |
| A | LEU741 |
| A | HIS744 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GAI A 1921 |
| Chain | Residue |
| A | SER604 |
| A | PHE605 |
| A | ASP606 |
| A | EDO1929 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GAI A 1922 |
| Chain | Residue |
| A | GLY715 |
| A | GLU843 |
| A | PHE844 |
| A | GLN847 |
| A | HOH2223 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 1923 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1924 |
| Chain | Residue |
| A | TYR633 |
| A | ASP649 |
| A | GLU650 |
| A | EDO1928 |
| B | LYS644 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 1925 |
| Chain | Residue |
| A | HIS682 |
| A | HOH2037 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1926 |
| Chain | Residue |
| A | PHE615 |
| A | ARG618 |
| A | PRO667 |
| A | ASN670 |
| A | TRP836 |
| A | ALA839 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1927 |
| Chain | Residue |
| A | LYS723 |
| A | GLN847 |
| A | GLU851 |
| A | VAL858 |
| A | LEU859 |
| A | PHE862 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1928 |
| Chain | Residue |
| A | LYS591 |
| A | ARG594 |
| A | EDO1924 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1929 |
| Chain | Residue |
| A | PHE605 |
| A | GLU611 |
| A | PHE612 |
| A | ASP613 |
| A | ARG616 |
| A | GAI1921 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT A 1930 |
| Chain | Residue |
| A | LEU753 |
| A | SER754 |
| A | ASP755 |
| A | PRO756 |
| A | ASP759 |
| A | ASP762 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI A 1931 |
| Chain | Residue |
| A | GLY646 |
| A | HOH2040 |
| A | HOH2224 |
| B | LEU694 |
| B | HOH2072 |
| B | HOH2080 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1932 |
| Chain | Residue |
| A | GLN643 |
| A | ASP649 |
| B | LYS644 |
| B | LEU697 |
| B | HOH2117 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1933 |
| Chain | Residue |
| A | GLY688 |
| A | ASN689 |
| A | LEU894 |
| A | GLN895 |
| A | GLY896 |
| A | HOH2225 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GAI A 1934 |
| Chain | Residue |
| A | GLU692 |
| A | LEU694 |
| A | HIS810 |
| site_id | BC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GAI A 1935 |
| Chain | Residue |
| A | LYS644 |
| A | PHE645 |
| A | GLY646 |
| A | GLY763 |
| B | GLU692 |
| B | LYS693 |
| B | GLU806 |
| B | HIS810 |
| B | HOH2074 |
| site_id | CC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE 8Z4 A 1936 |
| Chain | Residue |
| A | GLY873 |
| A | GLN874 |
| A | HOH2140 |
| A | MET785 |
| A | ASP822 |
| A | VAL840 |
| A | THR841 |
| A | TYR845 |
| A | MET861 |
| A | ASN867 |
| A | LEU870 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 1919 |
| Chain | Residue |
| B | HIS673 |
| B | HIS709 |
| B | ASP710 |
| B | ASP822 |
| B | HOH2062 |
| B | HOH2084 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1920 |
| Chain | Residue |
| B | ASP710 |
| B | HOH2060 |
| B | HOH2083 |
| B | HOH2084 |
| B | HOH2085 |
| B | HOH2104 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI B 1921 |
| Chain | Residue |
| B | GLY688 |
| B | ASN689 |
| B | LYS693 |
| B | LEU894 |
| B | GLN895 |
| B | GLY896 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GAI B 1922 |
| Chain | Residue |
| B | HOH2135 |
| B | HOH2142 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GAI B 1923 |
| Chain | Residue |
| B | HIS682 |
| B | HOH2036 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1924 |
| Chain | Residue |
| B | ASP606 |
| B | ASP609 |
| B | GLU611 |
| B | HOH2021 |
| site_id | CC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1937 |
| Chain | Residue |
| A | ARG769 |
| A | THR770 |
| B | GLU725 |
| site_id | CC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1925 |
| Chain | Residue |
| B | GLU698 |
| B | LEU771 |
| B | HIS810 |
| B | HOH2079 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FMT B 1926 |
| Chain | Residue |
| B | PHE615 |
| B | ARG618 |
| B | PRO667 |
| B | ASN670 |
| B | TRP836 |
| B | HOH2219 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GAI B 1927 |
| Chain | Residue |
| B | LEU753 |
| B | SER754 |
| B | ASP759 |
| B | ASP762 |
| B | LEU915 |
| B | HOH2173 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GAI B 1928 |
| Chain | Residue |
| B | ASP778 |
| B | LYS787 |
| B | HOH2147 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHmGlnNsF |
| Chain | Residue | Details |
| A | HIS709-PHE720 | |
