5G5T
Structure of the Argonaute protein from Methanocaldcoccus janaschii in complex with guide DNA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004520 | molecular_function | DNA endonuclease activity |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0044355 | biological_process | clearance of foreign intracellular DNA |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051607 | biological_process | defense response to virus |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1714 |
| Chain | Residue |
| A | GLN457 |
| A | GLN479 |
| A | LYS483 |
| D | DT1 |
| D | DA3 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1715 |
| Chain | Residue |
| A | GLY571 |
| A | ASP504 |
| A | THR505 |
| A | ARG569 |
| A | ASP570 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1716 |
| Chain | Residue |
| A | HIS145 |
| A | PHE616 |
| A | GLY617 |
| A | ASN618 |
| A | LYS651 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1717 |
| Chain | Residue |
| A | LYS163 |
| A | THR607 |
| A | SER608 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1718 |
| Chain | Residue |
| A | GLU18 |
| A | PHE19 |
| A | HIS110 |
| A | ARG293 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1719 |
| Chain | Residue |
| A | ASP296 |
| A | ASN297 |
| A | THR298 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1720 |
| Chain | Residue |
| A | HIS126 |
| A | LYS133 |
| A | LYS187 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1721 |
| Chain | Residue |
| A | GLU349 |
| A | LYS487 |
| A | ARG529 |
| A | HIS707 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 93 |
| Details | Domain: {"description":"PAZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00142","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"28319084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24442234","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Region: {"description":"Binds 3'-end of gDNA","evidences":[{"source":"PubMed","id":"28319084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G5T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 11 |
| Details | Region: {"description":"Binds 5'-phosphorylated end of gDNA","evidences":[{"source":"PubMed","id":"28319084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G5T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"Q746M7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5G5T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28319084","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q746M7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Site: {"description":"Interacts with gDNA","evidences":[{"source":"PubMed","id":"28319084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G5T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interacts with 3'-end of gDNA","evidences":[{"source":"PubMed","id":"28319084","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G5T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
