5G5K
Crystal structure of NagZ from Pseudomonas aeruginosa in complex with the inhibitor 2-acetamido-1,2-dideoxynojirimycin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0009254 | biological_process | peptidoglycan turnover |
| A | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0051301 | biological_process | cell division |
| A | 0071555 | biological_process | cell wall organization |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008360 | biological_process | regulation of cell shape |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0009254 | biological_process | peptidoglycan turnover |
| B | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0051301 | biological_process | cell division |
| B | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE NOK B 1333 |
| Chain | Residue |
| B | PHE33 |
| B | ASP62 |
| B | PHE114 |
| B | ARG131 |
| B | LYS161 |
| B | HIS162 |
| B | HIS174 |
| B | MET206 |
| B | ASP244 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE NOK A 1333 |
| Chain | Residue |
| A | PHE33 |
| A | ASP62 |
| A | PHE114 |
| A | ARG131 |
| A | LYS161 |
| A | HIS162 |
| A | ASP244 |
| A | MET248 |
Functional Information from PROSITE/UniProt
| site_id | PS00775 |
| Number of Residues | 18 |
| Details | GLYCOSYL_HYDROL_F3 Glycosyl hydrolases family 3 active site. ILRgElkfdGVIFSDdlS |
| Chain | Residue | Details |
| A | ILE230-SER247 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton donor/acceptor => ECO:0000255|HAMAP-Rule:MF_00364 |
| Chain | Residue | Details |
| A | HIS174 | |
| B | HIS174 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00364 |
| Chain | Residue | Details |
| A | ASP244 | |
| B | ASP244 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00364 |
| Chain | Residue | Details |
| A | ASP62 | |
| A | ARG70 | |
| A | ARG131 | |
| A | LYS161 | |
| B | ASP62 | |
| B | ARG70 | |
| B | ARG131 | |
| B | LYS161 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_00364 |
| Chain | Residue | Details |
| A | ASP172 | |
| B | ASP172 |
