Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5G1R

Open conformation of Francisella tularensis ClpP at 1.9 A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004176	molecular_function	ATP-dependent peptidase activity
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0009368	cellular_component	endopeptidase Clp complex
A	0016787	molecular_function	hydrolase activity
A	0051117	molecular_function	ATPase binding
B	0004176	molecular_function	ATP-dependent peptidase activity
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0009368	cellular_component	endopeptidase Clp complex
B	0016787	molecular_function	hydrolase activity
B	0051117	molecular_function	ATPase binding
C	0004176	molecular_function	ATP-dependent peptidase activity
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0009368	cellular_component	endopeptidase Clp complex
C	0016787	molecular_function	hydrolase activity
C	0051117	molecular_function	ATPase binding
D	0004176	molecular_function	ATP-dependent peptidase activity
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0009368	cellular_component	endopeptidase Clp complex
D	0016787	molecular_function	hydrolase activity
D	0051117	molecular_function	ATPase binding
E	0004176	molecular_function	ATP-dependent peptidase activity
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0009368	cellular_component	endopeptidase Clp complex
E	0016787	molecular_function	hydrolase activity
E	0051117	molecular_function	ATPase binding
F	0004176	molecular_function	ATP-dependent peptidase activity
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0009368	cellular_component	endopeptidase Clp complex
F	0016787	molecular_function	hydrolase activity
F	0051117	molecular_function	ATPase binding
G	0004176	molecular_function	ATP-dependent peptidase activity
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0006508	biological_process	proteolysis
G	0006515	biological_process	protein quality control for misfolded or incompletely synthesized proteins
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0009368	cellular_component	endopeptidase Clp complex
G	0016787	molecular_function	hydrolase activity
G	0051117	molecular_function	ATPase binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD A 800

Chain	Residue
A	TYR66
A	ILE94
A	TYR116
A	HOH2104
A	HOH2192
A	HOH2193

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 801

Chain	Residue
A	HIS126
A	LEU157
A	SER101
A	SER104
A	ILE125

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MRD B 800

Chain	Residue
B	TYR66
B	TYR116
B	ILE193
B	ARG196

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 801

Chain	Residue
B	SER101
B	SER104
B	LEU105
B	ILE125
B	HIS126

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT B 802

Chain	Residue
B	TYR24
B	HOH2028
B	HOH2164

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MRD C 800

Chain	Residue
C	TYR64
C	TYR66

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT C 801

Chain	Residue
C	SER101
C	MET102
C	SER104
C	ILE125
C	HIS126
C	HOH2050

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT D 800

Chain	Residue
D	SER101
D	SER104
D	LEU105
D	ILE125
D	HIS126

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MPD E 800

Chain	Residue
E	TYR64
E	SER92
E	ILE94
E	TYR116
E	ILE193
F	PHE86

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD F 800

Chain	Residue
F	TYR64
F	ILE94
F	ILE193
F	ARG196
F	HOH2221

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT F 801

Chain	Residue
F	SER101
F	SER104
F	LEU105
F	ILE125
F	HIS126

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT G 800

Chain	Residue
G	SER101
G	SER104
G	LEU105
G	ILE125
G	HIS126

Functional Information from PROSITE/UniProt

site_id	PS00381
Number of Residues	12
Details	CLP_PROTEASE_SER Endopeptidase Clp serine active site. TicIGlAASMGS

Chain	Residue	Details
A	THR93-SER104

site_id	PS00382
Number of Residues	14
Details	CLP_PROTEASE_HIS Endopeptidase Clp histidine active site. RyslPssqIMIHQP

Chain	Residue	Details
A	ARG115-PRO128

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	7
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00444","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)