Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0040029 | biological_process | epigenetic regulation of gene expression |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0040029 | biological_process | epigenetic regulation of gene expression |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 370 |
| Chain | Residue |
| A | ASP180 |
| A | HIS182 |
| A | ASP268 |
| A | 9RB373 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 371 |
| Chain | Residue |
| A | ASP178 |
| A | ASP180 |
| A | HIS182 |
| A | SER201 |
| A | LEU202 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 372 |
| Chain | Residue |
| A | TRP191 |
| A | ASP194 |
| A | VAL197 |
| A | THR199 |
| A | TYR226 |
| A | HOH2300 |
| A | HOH2309 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 9RB A 373 |
| Chain | Residue |
| A | LEU21 |
| A | HIS142 |
| A | HIS143 |
| A | GLY151 |
| A | PHE152 |
| A | ASP180 |
| A | HIS182 |
| A | PHE208 |
| A | ASP268 |
| A | TYR312 |
| A | PHE341 |
| A | ZN370 |
| A | HOH2275 |
| A | HOH2295 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE 1PE A 374 |
| Chain | Residue |
| A | ARG173 |
| A | PRO195 |
| A | ASN222 |
| A | TYR226 |
| A | ARG369 |
| A | HOH2289 |
| A | HOH2484 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 375 |
| Chain | Residue |
| A | THR349 |
| A | PEG376 |
| A | HOH2485 |
| B | HOH2475 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE PEG A 376 |
| Chain | Residue |
| A | HIS205 |
| A | PRO231 |
| A | LEU232 |
| A | PRO233 |
| A | PRO234 |
| A | GLU360 |
| A | PEG375 |
| A | HOH2320 |
| A | HOH2321 |
| A | HOH2470 |
| A | HOH2471 |
| A | HOH2486 |
| A | HOH2487 |
| A | HOH2488 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG A 377 |
| Chain | Residue |
| A | ARG355 |
| A | HOH2489 |
| A | HOH2490 |
| A | HOH2492 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PEG A 378 |
| Chain | Residue |
| A | ASP352 |
| A | ALA353 |
| A | HOH2464 |
| A | HOH2467 |
| A | HOH2495 |
| B | ASP352 |
| B | ALA353 |
| B | HOH2478 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 370 |
| Chain | Residue |
| B | ASP180 |
| B | HIS182 |
| B | ASP268 |
| B | 9RB373 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 371 |
| Chain | Residue |
| B | ASP178 |
| B | ASP180 |
| B | HIS182 |
| B | SER201 |
| B | LEU202 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K B 372 |
| Chain | Residue |
| B | TRP191 |
| B | ASP194 |
| B | VAL197 |
| B | THR199 |
| B | TYR226 |
| B | HOH2305 |
| B | HOH2314 |
| site_id | BC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 9RB B 373 |
| Chain | Residue |
| B | LEU21 |
| B | ALA22 |
| B | HIS142 |
| B | HIS143 |
| B | GLY151 |
| B | PHE152 |
| B | ASP180 |
| B | HIS182 |
| B | PHE208 |
| B | ASP268 |
| B | TYR312 |
| B | PHE341 |
| B | ZN370 |
| B | HOH2052 |
| B | HOH2278 |
| B | HOH2450 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE 1PE B 374 |
| Chain | Residue |
| B | GLU172 |
| B | ARG173 |
| B | PRO195 |
| B | TYR226 |
| B | HOH2391 |
| B | HOH2488 |
| B | HOH2490 |
| B | HOH2491 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEG B 375 |
| Chain | Residue |
| B | LYS85 |
| B | SER88 |
| B | ASN89 |
| B | GLY106 |
| B | GLU109 |
| B | HOH2190 |
| B | HOH2233 |
| B | HOH2234 |
| B | HOH2492 |
| B | HOH2493 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG B 376 |
| Chain | Residue |
| B | ASP283 |
| B | HIS339 |
| B | HOH2366 |
| B | HOH2460 |
| B | HOH2494 |
| site_id | BC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PEG B 377 |
| Chain | Residue |
| B | ASN238 |
| B | ALA239 |
| B | LEU242 |
| B | ASP283 |
| B | GLN287 |
| B | HOH2366 |
| B | HOH2367 |
| B | HOH2465 |
| B | HOH2466 |
| B | HOH2468 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27756124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1C","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
