Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004407 | molecular_function | histone deacetylase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0040029 | biological_process | epigenetic regulation of gene expression |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004407 | molecular_function | histone deacetylase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0040029 | biological_process | epigenetic regulation of gene expression |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 370 |
| Chain | Residue |
| A | ASP180 |
| A | HIS182 |
| A | ASP268 |
| A | 6DK373 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 371 |
| Chain | Residue |
| A | ASP178 |
| A | ASP180 |
| A | HIS182 |
| A | SER201 |
| A | LEU202 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 372 |
| Chain | Residue |
| A | TRP191 |
| A | ASP194 |
| A | VAL197 |
| A | TYR226 |
| A | HOH2296 |
| A | HOH2303 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 6DK A 373 |
| Chain | Residue |
| A | PRO140 |
| A | HIS142 |
| A | HIS143 |
| A | GLY151 |
| A | PHE152 |
| A | CYS153 |
| A | ASP180 |
| A | HIS182 |
| A | PHE208 |
| A | ASP268 |
| A | GLU309 |
| A | GLY310 |
| A | TYR312 |
| A | PHE341 |
| A | ZN370 |
| A | HOH2103 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 370 |
| Chain | Residue |
| B | ASP180 |
| B | HIS182 |
| B | ASP268 |
| B | 6DK373 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 371 |
| Chain | Residue |
| B | ASP178 |
| B | ASP180 |
| B | HIS182 |
| B | SER201 |
| B | LEU202 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 372 |
| Chain | Residue |
| B | TRP191 |
| B | ASP194 |
| B | VAL197 |
| B | TYR226 |
| B | HOH2297 |
| B | HOH2306 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 6DK B 373 |
| Chain | Residue |
| B | PRO140 |
| B | HIS142 |
| B | HIS143 |
| B | GLY151 |
| B | PHE152 |
| B | CYS153 |
| B | ASP180 |
| B | HIS182 |
| B | PHE208 |
| B | ASP268 |
| B | GLU309 |
| B | GLY310 |
| B | TYR312 |
| B | PHE341 |
| B | ZN370 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27756124","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1C","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"Polarizes the scissile carbonyl of the substrate","evidences":[{"source":"UniProtKB","id":"Q48935","evidenceCode":"ECO:0000250"}]} |
