5FYD

Structural and biochemical insights into 7beta-hydroxysteroid dehydrogenase stereoselectivity

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0006629	biological_process	lipid metabolic process
A	0008202	biological_process	steroid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0030573	biological_process	bile acid catabolic process
A	0047022	molecular_function	7-beta-hydroxysteroid dehydrogenase (NADP+) activity
B	0000166	molecular_function	nucleotide binding
B	0006629	biological_process	lipid metabolic process
B	0008202	biological_process	steroid metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0030573	biological_process	bile acid catabolic process
B	0047022	molecular_function	7-beta-hydroxysteroid dehydrogenase (NADP+) activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1260

Chain	Residue
A	GLU74
B	HOH2078
A	TRP105
A	HOH2062
A	HOH2063
B	GLU74
B	PHE77
B	LYS121
B	HIS124
B	HIS125

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"27006087","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28471355","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5GT9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"27006087","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Lowers pKa of active site Tyr","evidences":[{"source":"UniProtKB","id":"P0AET8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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