5FY4
Crystal structure of the catalytic domain of human JARID1B in complex with succinate
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1754 |
| Chain | Residue |
| A | CYS692 |
| A | CYS695 |
| A | CYS715 |
| A | HIS718 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 1755 |
| Chain | Residue |
| A | HOH2040 |
| A | LEU90 |
| A | LEU413 |
| A | THR416 |
| A | GLU419 |
| A | HOH2038 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1757 |
| Chain | Residue |
| A | SER677 |
| A | LEU732 |
| A | THR737 |
| A | EDO1762 |
| A | HOH2194 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1758 |
| Chain | Residue |
| A | ARG612 |
| A | ASP630 |
| A | MET658 |
| A | GLU662 |
| A | HOH2161 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1759 |
| Chain | Residue |
| A | PRO30 |
| A | PRO567 |
| A | VAL568 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1760 |
| Chain | Residue |
| A | ASP688 |
| A | GLU689 |
| A | ARG690 |
| A | GLN691 |
| A | VAL693 |
| A | GLY711 |
| A | LEU712 |
| A | LEU713 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1761 |
| Chain | Residue |
| A | GLY524 |
| A | TYR525 |
| A | ARG584 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1762 |
| Chain | Residue |
| A | ARG670 |
| A | VAL674 |
| A | ILE675 |
| A | EDO1757 |
| A | HOH2081 |
| A | HOH2193 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 1763 |
| Chain | Residue |
| A | HIS564 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 1764 |
| Chain | Residue |
| A | VAL398 |
| A | VAL398 |
| A | HIS399 |
| A | HIS399 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 1765 |
| Chain | Residue |
| A | HIS499 |
| A | GLU501 |
| A | HIS587 |
| A | FUM1767 |
| A | HOH2047 |
| A | HOH2107 |
| site_id | BC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FUM A 1767 |
| Chain | Residue |
| A | TYR425 |
| A | TYR488 |
| A | PHE496 |
| A | HIS499 |
| A | ASN509 |
| A | LYS517 |
| A | TRP519 |
| A | HIS587 |
| A | MN1765 |
| A | HOH2045 |
| A | HOH2047 |
| A | HOH2107 |
| A | HOH2237 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 41 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 52 |
| Details | Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P29375","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
