Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5FXY

Structure of the human RBBP4:MTA1(464-546) complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000781	cellular_component	chromosome, telomeric region
A	0000785	cellular_component	chromatin
A	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006281	biological_process	DNA repair
A	0006325	biological_process	chromatin organization
A	0006334	biological_process	nucleosome assembly
A	0006335	biological_process	DNA replication-dependent chromatin assembly
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006974	biological_process	DNA damage response
A	0007420	biological_process	brain development
A	0008094	molecular_function	ATP-dependent activity, acting on DNA
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016581	cellular_component	NuRD complex
A	0016589	cellular_component	NURF complex
A	0030336	biological_process	negative regulation of cell migration
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0031492	molecular_function	nucleosomal DNA binding
A	0032991	cellular_component	protein-containing complex
A	0033186	cellular_component	CAF-1 complex
A	0035098	cellular_component	ESC/E(Z) complex
A	0042393	molecular_function	histone binding
A	0042659	biological_process	regulation of cell fate specification
A	0042826	molecular_function	histone deacetylase binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0070822	cellular_component	Sin3-type complex
A	1902455	biological_process	negative regulation of stem cell population maintenance
A	1902459	biological_process	positive regulation of stem cell population maintenance
A	1904949	cellular_component	ATPase complex
A	2000736	biological_process	regulation of stem cell differentiation
C	0000118	cellular_component	histone deacetylase complex
C	0000122	biological_process	negative regulation of transcription by RNA polymerase II
C	0000781	cellular_component	chromosome, telomeric region
C	0000785	cellular_component	chromatin
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006260	biological_process	DNA replication
C	0006281	biological_process	DNA repair
C	0006325	biological_process	chromatin organization
C	0006334	biological_process	nucleosome assembly
C	0006335	biological_process	DNA replication-dependent chromatin assembly
C	0006338	biological_process	chromatin remodeling
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006974	biological_process	DNA damage response
C	0007420	biological_process	brain development
C	0008094	molecular_function	ATP-dependent activity, acting on DNA
C	0008285	biological_process	negative regulation of cell population proliferation
C	0016581	cellular_component	NuRD complex
C	0016589	cellular_component	NURF complex
C	0030336	biological_process	negative regulation of cell migration
C	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
C	0031492	molecular_function	nucleosomal DNA binding
C	0032991	cellular_component	protein-containing complex
C	0033186	cellular_component	CAF-1 complex
C	0035098	cellular_component	ESC/E(Z) complex
C	0042393	molecular_function	histone binding
C	0042659	biological_process	regulation of cell fate specification
C	0042826	molecular_function	histone deacetylase binding
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	0070822	cellular_component	Sin3-type complex
C	1902455	biological_process	negative regulation of stem cell population maintenance
C	1902459	biological_process	positive regulation of stem cell population maintenance
C	1904949	cellular_component	ATPase complex
C	2000736	biological_process	regulation of stem cell differentiation
E	0000118	cellular_component	histone deacetylase complex
E	0000122	biological_process	negative regulation of transcription by RNA polymerase II
E	0000781	cellular_component	chromosome, telomeric region
E	0000785	cellular_component	chromatin
E	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006260	biological_process	DNA replication
E	0006281	biological_process	DNA repair
E	0006325	biological_process	chromatin organization
E	0006334	biological_process	nucleosome assembly
E	0006335	biological_process	DNA replication-dependent chromatin assembly
E	0006338	biological_process	chromatin remodeling
E	0006355	biological_process	regulation of DNA-templated transcription
E	0006974	biological_process	DNA damage response
E	0007420	biological_process	brain development
E	0008094	molecular_function	ATP-dependent activity, acting on DNA
E	0008285	biological_process	negative regulation of cell population proliferation
E	0016581	cellular_component	NuRD complex
E	0016589	cellular_component	NURF complex
E	0030336	biological_process	negative regulation of cell migration
E	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
E	0031492	molecular_function	nucleosomal DNA binding
E	0032991	cellular_component	protein-containing complex
E	0033186	cellular_component	CAF-1 complex
E	0035098	cellular_component	ESC/E(Z) complex
E	0042393	molecular_function	histone binding
E	0042659	biological_process	regulation of cell fate specification
E	0042826	molecular_function	histone deacetylase binding
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	0070822	cellular_component	Sin3-type complex
E	1902455	biological_process	negative regulation of stem cell population maintenance
E	1902459	biological_process	positive regulation of stem cell population maintenance
E	1904949	cellular_component	ATPase complex
E	2000736	biological_process	regulation of stem cell differentiation
G	0000118	cellular_component	histone deacetylase complex
G	0000122	biological_process	negative regulation of transcription by RNA polymerase II
G	0000781	cellular_component	chromosome, telomeric region
G	0000785	cellular_component	chromatin
G	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006260	biological_process	DNA replication
G	0006281	biological_process	DNA repair
G	0006325	biological_process	chromatin organization
G	0006334	biological_process	nucleosome assembly
G	0006335	biological_process	DNA replication-dependent chromatin assembly
G	0006338	biological_process	chromatin remodeling
G	0006355	biological_process	regulation of DNA-templated transcription
G	0006974	biological_process	DNA damage response
G	0007420	biological_process	brain development
G	0008094	molecular_function	ATP-dependent activity, acting on DNA
G	0008285	biological_process	negative regulation of cell population proliferation
G	0016581	cellular_component	NuRD complex
G	0016589	cellular_component	NURF complex
G	0030336	biological_process	negative regulation of cell migration
G	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
G	0031492	molecular_function	nucleosomal DNA binding
G	0032991	cellular_component	protein-containing complex
G	0033186	cellular_component	CAF-1 complex
G	0035098	cellular_component	ESC/E(Z) complex
G	0042393	molecular_function	histone binding
G	0042659	biological_process	regulation of cell fate specification
G	0042826	molecular_function	histone deacetylase binding
G	0045892	biological_process	negative regulation of DNA-templated transcription
G	0045893	biological_process	positive regulation of DNA-templated transcription
G	0070822	cellular_component	Sin3-type complex
G	1902455	biological_process	negative regulation of stem cell population maintenance
G	1902459	biological_process	positive regulation of stem cell population maintenance
G	1904949	cellular_component	ATPase complex
G	2000736	biological_process	regulation of stem cell differentiation

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTICLWDI

Chain	Residue	Details
A	LEU193-ILE207
A	LEU289-LEU303
A	LEU333-LEU347

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	172
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	224
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	128
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"39460621","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8TX8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q60972","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25755297","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)