5FWA

Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with CP1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006338	biological_process	chromatin remodeling
A	0008168	molecular_function	methyltransferase activity
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0018216	biological_process	peptidyl-arginine methylation
A	0032259	biological_process	methylation
A	0042054	molecular_function	histone methyltransferase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE J7C A 1446

Chain	Residue
A	TYR114
A	VAL208
A	GLU209
A	GLU223
A	TRP224
A	MET225
A	GLU232
A	MET234
A	SER237
A	HOH2018
A	HOH2139
A	PHE115
A	TYR118
A	HIS124
A	GLY157
A	GLU180
A	ALA181
A	SER182
A	LYS207

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 A 1447

Chain	Residue
A	ASP150
A	LYS151
A	ASP218
A	ASP249
A	LEU362

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 1448

Chain	Residue
A	GLY374
A	PRO375
A	LEU376
A	HIS377

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1449

Chain	Residue
A	ARG299

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1450

Chain	Residue
A	PRO375
A	HIS377

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site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1451

Chain	Residue
A	GLN110
A	TYR114
A	PHE231
A	HOH2303

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site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 1452

Chain	Residue
A	GLY196
A	ASP199
A	HOH2087
A	HOH2089

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site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 1453

Chain	Residue
A	HOH2033
A	HOH2033
A	HOH2038
A	HOH2038

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