5FW2
Crystal structure of SpCas9 variant EQR bound to sgRNA and TGAG PAM target DNA
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004519 | molecular_function | endonuclease activity |
| B | 0004520 | molecular_function | DNA endonuclease activity |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0043571 | biological_process | maintenance of CRISPR repeat elements |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051607 | biological_process | defense response to virus |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE K A 1182 |
| 鎖名 | 残基 |
| A | G21 |
| A | HOH2001 |
| A | HOH2022 |
| A | HOH2023 |
| A | HOH2037 |
| A | HOH2038 |
| site_id | AC2 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE K A 1183 |
| 鎖名 | 残基 |
| A | U12 |
| A | G13 |
| A | HOH2012 |
| site_id | AC3 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE MG A 1084 |
| 鎖名 | 残基 |
| A | U50 |
| A | HOH2052 |
| A | HOH2053 |
| A | HOH2054 |
| A | HOH2055 |
| A | HOH2064 |
| site_id | AC4 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE K B 2366 |
| 鎖名 | 残基 |
| A | A68 |
| A | HOH2081 |
| B | GLN1350 |
| B | HOH2075 |
| B | HOH2105 |
| site_id | AC5 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE K B 2367 |
| 鎖名 | 残基 |
| B | GLU584 |
| B | ARG586 |
| B | ASN588 |
| B | HOH2052 |
| B | HOH2053 |
| site_id | AC6 |
| 残基数 | 7 |
| 詳細 | BINDING SITE FOR RESIDUE K B 2368 |
| 鎖名 | 残基 |
| A | A65 |
| A | U66 |
| A | HOH2072 |
| A | HOH2073 |
| A | HOH2077 |
| A | HOH2078 |
| B | THR1102 |
| site_id | AC7 |
| 残基数 | 6 |
| 詳細 | BINDING SITE FOR RESIDUE K B 2369 |
| 鎖名 | 残基 |
| B | LEU623 |
| B | THR624 |
| B | PHE626 |
| B | TYR656 |
| B | HOH2057 |
| C | HOH2007 |
| site_id | AC8 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE K B 2370 |
| 鎖名 | 残基 |
| B | GLY361 |
| B | TYR362 |
| B | GLY365 |
| B | GLY366 |
| B | ALA367 |
| site_id | AC9 |
| 残基数 | 2 |
| 詳細 | BINDING SITE FOR RESIDUE K B 2371 |
| 鎖名 | 残基 |
| B | ALA640 |
| B | PHE643 |
| site_id | BC1 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE K B 2372 |
| 鎖名 | 残基 |
| A | HOH2073 |
| B | THR1102 |
| B | HOH2001 |
| B | HOH2007 |
| site_id | BC2 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE K B 2373 |
| 鎖名 | 残基 |
| B | LYS111 |
| B | HOH2011 |
| B | HOH2012 |
| B | HOH2013 |
| site_id | BC3 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE MG A 1083 |
| 鎖名 | 残基 |
| A | HOH2021 |
| A | HOH2023 |
| A | HOH2024 |
| A | HOH2087 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 1 |
| 詳細 | ACT_SITE: For RuvC-like nuclease domain => ECO:0000305|PubMed:24529477 |
| 鎖名 | 残基 | 詳細 |
| B | ALA10 |
| site_id | SWS_FT_FI2 |
| 残基数 | 1 |
| 詳細 | ACT_SITE: Proton acceptor for HNH nuclease domain => ECO:0000305|PubMed:24529477 |
| 鎖名 | 残基 | 詳細 |
| B | ALA840 |
| site_id | SWS_FT_FI3 |
| 残基数 | 6 |
| 詳細 | BINDING: BINDING => ECO:0000269|PubMed:24505130 |
| 鎖名 | 残基 | 詳細 |
| B | ALA10 | |
| B | GLU762 | |
| B | GLU766 | |
| B | HIS983 | |
| B | HIS1297 | |
| B | ASP1328 |
