5FUP

Crystal structure of human JARID1B in complex with 2-oxoglutarate.

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1755

Chain	Residue
A	CYS692
A	CYS695
A	CYS715
A	HIS718

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1756

Chain	Residue
A	CYS706
A	CYS708
A	CYS723
A	CYS725

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A 1757

Chain	Residue
A	GLU501
A	HIS587
A	AKG1764
A	HOH2252
A	HIS499

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MN A 1758

Chain	Residue
A	HOH2456

---

site_id	AC5
Number of Residues	16
Details	BINDING SITE FOR RESIDUE EPE A 1759

Chain	Residue
A	ILE500
A	TRP504
A	LEU541
A	LEU552
A	VAL553
A	TYR586
A	HIS617
A	TYR618
A	LEU621
A	ARG623
A	HOH2250
A	HOH2256
A	HOH2289
A	HOH2318
A	HOH2360
A	HOH2482

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 1762

Chain	Residue
A	LEU90
A	ASN91
A	LEU413
A	THR416
A	GLU419
A	HOH2111

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 2760

Chain	Residue
A	ASP630
A	CYS699
A	PHE700
A	MET701
A	SER702
A	HOH2369

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 2762

Chain	Residue
A	TYR734
A	HOH2468
A	HOH2485

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 2763

Chain	Residue
A	ARG612
A	ASP630
A	MET658
A	ASP661
A	GLU662
A	HOH2455

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 2764

Chain	Residue
A	PRO30
A	VAL568

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO A 2765

Chain	Residue
A	ASP688
A	GLU689
A	ARG690
A	GLN691
A	VAL693
A	GLY711
A	LEU712
A	LEU713
A	HOH2488

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 2766

Chain	Residue
A	GLY524
A	TYR525
A	ARG584
A	HOH2277
A	HOH2489

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 2767

Chain	Residue
A	ARG670
A	VAL674
A	ILE675
A	HOH2179
A	HOH2397

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 2768

Chain	Residue
A	TRP70
A	GLU453
A	SER457
A	HOH2039

---

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 2769

Chain	Residue
A	TYR488
A	GLU501
A	ALA599
A	ASN601
A	AKG1764
A	HOH2234
A	HOH2252
A	HOH2490

---

site_id	BC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AKG A 1764

Chain	Residue
A	TYR425
A	TYR488
A	PHE496
A	HIS499
A	GLU501
A	SER507
A	ASN509
A	LYS517
A	TRP519
A	HIS587
A	ALA599
A	MN1757
A	HOH2252
A	HOH2483
A	EDO2769

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	41
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	52
Details	Zinc finger: {"description":"C5HC2","evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P29375","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27214403","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28262558","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---