5FT5
Crystal structure of the cysteine desulfurase CsdA (persulfurated) from Escherichia coli at 2.384 Angstroem resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000096 | biological_process | sulfur amino acid metabolic process |
| A | 0005515 | molecular_function | protein binding |
| A | 0006534 | biological_process | cysteine metabolic process |
| A | 0008826 | molecular_function | cysteine sulfinate desulfinase activity |
| A | 0009000 | molecular_function | selenocysteine lyase activity |
| A | 0016226 | biological_process | iron-sulfur cluster assembly |
| A | 0016261 | biological_process | selenocysteine catabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016783 | molecular_function | sulfurtransferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019448 | biological_process | L-cysteine catabolic process |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0031071 | molecular_function | cysteine desulfurase activity |
| A | 0072348 | biological_process | sulfur compound transport |
| A | 1990221 | cellular_component | L-cysteine desulfurase complex |
| B | 0000096 | biological_process | sulfur amino acid metabolic process |
| B | 0005515 | molecular_function | protein binding |
| B | 0006534 | biological_process | cysteine metabolic process |
| B | 0008826 | molecular_function | cysteine sulfinate desulfinase activity |
| B | 0009000 | molecular_function | selenocysteine lyase activity |
| B | 0016226 | biological_process | iron-sulfur cluster assembly |
| B | 0016261 | biological_process | selenocysteine catabolic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016783 | molecular_function | sulfurtransferase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019448 | biological_process | L-cysteine catabolic process |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0031071 | molecular_function | cysteine desulfurase activity |
| B | 0072348 | biological_process | sulfur compound transport |
| B | 1990221 | cellular_component | L-cysteine desulfurase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1402 |
| Chain | Residue |
| A | THR28 |
| B | ALA47 |
| B | THR273 |
| B | VAL276 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1402 |
| Chain | Residue |
| A | GOL1406 |
| A | ARG302 |
| A | PRO316 |
| A | GLN324 |
| A | ALA334 |
| A | VAL400 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1403 |
| Chain | Residue |
| A | TYR65 |
| A | ARG69 |
| A | TRP86 |
| A | HOH2034 |
| A | HOH2035 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1404 |
| Chain | Residue |
| A | ALA63 |
| A | ARG64 |
| A | LYS71 |
| A | GLU287 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1405 |
| Chain | Residue |
| A | HIS338 |
| A | SER339 |
| A | HOH2130 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1406 |
| Chain | Residue |
| A | VAL400 |
| A | GOL1402 |
| A | HOH2116 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1407 |
| Chain | Residue |
| A | PHE4 |
| A | TRP300 |
| A | ARG319 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG A 1408 |
| Chain | Residue |
| A | ARG10 |
| A | TRP300 |
| A | THR381 |
| A | LYS382 |
| A | SER383 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE TLA A 1409 |
| Chain | Residue |
| A | ALA26 |
| A | ALA27 |
| A | HIS119 |
| A | ASN171 |
| A | LYS222 |
| A | ARG353 |
| A | HIS357 |
| A | CSS358 |
| A | ARG373 |
| A | PLP1410 |
| B | LYS250 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP A 1410 |
| Chain | Residue |
| A | THR90 |
| A | THR91 |
| A | HIS119 |
| A | ASN171 |
| A | ASP196 |
| A | ALA198 |
| A | GLN199 |
| A | SER219 |
| A | HIS221 |
| A | LYS222 |
| A | TLA1409 |
| A | HOH2043 |
| A | HOH2152 |
| B | GLY272 |
| B | THR273 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 1403 |
| Chain | Residue |
| B | TYR65 |
| B | GLU66 |
| B | ALA68 |
| B | ARG69 |
| B | TRP86 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1404 |
| Chain | Residue |
| A | ASP151 |
| B | ARG10 |
| B | THR381 |
| B | SER383 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1405 |
| Chain | Residue |
| B | HIS51 |
| B | ARG52 |
| B | PHE55 |
| B | PHE204 |
| B | ARG302 |
| B | GLN324 |
| B | HOH2132 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE TLA B 1406 |
| Chain | Residue |
| B | HIS119 |
| B | LYS222 |
| B | ARG353 |
| B | HIS357 |
| B | CSS358 |
| B | ARG373 |
| B | PLP1407 |
| B | HOH2147 |
| site_id | BC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PLP B 1407 |
| Chain | Residue |
| A | GLY272 |
| A | THR273 |
| B | THR90 |
| B | THR91 |
| B | HIS119 |
| B | ALA121 |
| B | ASP196 |
| B | ALA198 |
| B | GLN199 |
| B | SER219 |
| B | HIS221 |
| B | LYS222 |
| B | TLA1406 |
| B | HOH2052 |
| B | HOH2147 |
Functional Information from PROSITE/UniProt
| site_id | PS00595 |
| Number of Residues | 20 |
| Details | AA_TRANSFER_CLASS_5 Aminotransferases class-V pyridoxal-phosphate attachment site. IDFYafSGHKlygpt.GiGvL |
| Chain | Residue | Details |
| A | ILE213-LEU232 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Cysteine persulfide intermediate","evidences":[{"source":"PubMed","id":"10739946","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
