Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1003 |
| Chain | Residue |
| A | TYR193 |
| A | THR194 |
| A | ILE197 |
| A | ASP200 |
| A | HOH2371 |
| A | HOH2375 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1004 |
| Chain | Residue |
| A | GLU190 |
| A | HOH2353 |
| A | HOH2361 |
| A | GLU177 |
| A | ASN183 |
| A | ASP185 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1005 |
| Chain | Residue |
| A | ASP59 |
| A | GLN61 |
| A | CA1010 |
| A | HOH2172 |
| A | HOH2179 |
| A | HOH2545 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 1006 |
| Chain | Residue |
| A | HIS142 |
| A | HIS146 |
| A | TYR157 |
| A | GLU166 |
| A | HIS231 |
| A | VAL1001 |
| A | ZN1007 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1007 |
| Chain | Residue |
| A | HIS142 |
| A | HIS146 |
| A | GLU166 |
| A | ZN1006 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE OXY A 1008 |
| Chain | Residue |
| A | TYR84 |
| A | SER92 |
| A | TYR93 |
| A | ILE100 |
| A | LEU144 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1009 |
| Chain | Residue |
| A | ASP138 |
| A | GLU177 |
| A | ASP185 |
| A | GLU187 |
| A | GLU190 |
| A | HOH2318 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1010 |
| Chain | Residue |
| A | ASP57 |
| A | ASP59 |
| A | GLN61 |
| A | CA1005 |
| A | HOH2171 |
| A | HOH2172 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | Binding site for Di-peptide VAL A1001 and LYS A1002 |
| Chain | Residue |
| A | ASN111 |
| A | ASN112 |
| A | ALA113 |
| A | PHE130 |
| A | GLU143 |
| A | LEU202 |
| A | ARG203 |
| A | HIS231 |
| A | ZN1006 |
| A | HOH2435 |
| A | HOH2541 |
| A | HOH2542 |
| A | HOH2544 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVAHELTHAV |
| Chain | Residue | Details |
| A | VAL139-VAL148 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"4808703","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 16 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 176 |
| Chain | Residue | Details |
| A | HIS142 | metal ligand |
| A | GLU143 | electrostatic stabiliser, metal ligand |
| A | HIS146 | metal ligand |
| A | TYR157 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | GLU166 | metal ligand |
| A | ASP226 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS231 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
