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5FQM

Last common ancestor of Gram Negative Bacteria (GNCA) Class A beta- lactamase

Functional Information from GO Data
ChainGOidnamespacecontents
A0008800molecular_functionbeta-lactamase activity
A0017001biological_processantibiotic catabolic process
A0030655biological_processbeta-lactam antibiotic catabolic process
A0046677biological_processresponse to antibiotic
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE SO4 A 1293
ChainResidue
ASER70
ALYS88
ASER130
ATHR235
AGLY236
ATHR237
AHOH2088
AHOH2146
AHOH2169

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 1294
ChainResidue
AGLN86
APHE151
ASER154
AILE155
AGLU171
AHOH2196
AHOH2197
AHOH2298
AHOH2299

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 1295
ChainResidue
ALYS215
ATHR216
AGLY217
AASP218

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 1296
ChainResidue
AARG161
AGOL1304
AHOH2302

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 1297
ChainResidue
AILE155
AGLU171
AALA173
ATHR192
AHIS241
AHOH2197
AHOH2303

site_idAC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL A 1298
ChainResidue
AARG43
AARG65
APRO67
APRO174
AGLY175
AASP176
AHOH2025
AHOH2201
AHOH2304
AHOH2305

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 1299
ChainResidue
AILE155
AASP157
AALA185
AALA188
ATHR189
ATHR192

site_idAC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 1300
ChainResidue
AALA120
AGLU124
AGLN206
ATRP210
AASP228
AHOH2163
AHOH2307

site_idAC9
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GOL A 1301
ChainResidue
AASP197
ASER200
APRO201
AHIS241
AGLY242
ASER268
AGLN269
AHOH2220
AHOH2266
AHOH2274
AHOH2308

site_idBC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL A 1302
ChainResidue
ALEU102
AVAL103
AASP104
AALA146
AALA147
AALA150
APRO167
AHOH2179
AHOH2180
AHOH2309

site_idBC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 1303
ChainResidue
AALA58
ATYR60
AARG61
AGLY62
AHOH2004
AHOH2005
AHOH2071

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL A 1304
ChainResidue
AARG153
AARG161
AASP163
AGOL1296

Functional Information from PROSITE/UniProt
site_idPS00146
Number of Residues16
DetailsBETA_LACTAMASE_A Beta-lactamase class-A active site. FpMCSTfKallAAAVL
ChainResidueDetails
APHE66-LEU81

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PDB entries from 2024-11-06

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