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5FPY

Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 5-bromo-1-methyl-1H-indole-2-carboxylic acid (AT21457) in an alternate binding site.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004386molecular_functionhelicase activity
A0005524molecular_functionATP binding
A0006508biological_processproteolysis
A0008236molecular_functionserine-type peptidase activity
A0019087biological_processsymbiont-mediated transformation of host cell
B0004386molecular_functionhelicase activity
B0005524molecular_functionATP binding
B0006508biological_processproteolysis
B0008236molecular_functionserine-type peptidase activity
B0019087biological_processsymbiont-mediated transformation of host cell
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE R2N B 1721
ChainResidue
BSER370
BLYS371
BVAL432
BHOH2200

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE R2N A 1721
ChainResidue
ASER370
ALYS371
AVAL432
AGLN434
AHOH2403

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues304
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues22
DetailsRegion: {"description":"RNA-binding","evidences":[{"source":"PubMed","id":"9614113","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsMotif: {"description":"DECH box","evidences":[{"source":"UniProtKB","id":"Q99IB8","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsActive site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues2
DetailsActive site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9568891","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10366511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9568891","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10366511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues14
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q9WMX2","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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