5FPY
Structure of hepatitis C virus (HCV) full-length NS3 complex with small-molecule ligand 5-bromo-1-methyl-1H-indole-2-carboxylic acid (AT21457) in an alternate binding site.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004386 | molecular_function | helicase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006508 | biological_process | proteolysis |
A | 0008236 | molecular_function | serine-type peptidase activity |
A | 0019087 | biological_process | symbiont-mediated transformation of host cell |
B | 0004386 | molecular_function | helicase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006508 | biological_process | proteolysis |
B | 0008236 | molecular_function | serine-type peptidase activity |
B | 0019087 | biological_process | symbiont-mediated transformation of host cell |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE R2N B 1721 |
Chain | Residue |
B | SER370 |
B | LYS371 |
B | VAL432 |
B | HOH2200 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE R2N A 1721 |
Chain | Residue |
A | SER370 |
A | LYS371 |
A | VAL432 |
A | GLN434 |
A | HOH2403 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 304 |
Details | Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 22 |
Details | Region: {"description":"RNA-binding","evidences":[{"source":"PubMed","id":"9614113","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | Motif: {"description":"DECH box","evidences":[{"source":"UniProtKB","id":"Q99IB8","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | Active site: {"description":"Charge relay system; for serine protease NS3 activity","evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9568891","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10366511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9568891","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01166","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10366511","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8861916","evidenceCode":"ECO:0000269"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI8 |
Number of Residues | 14 |
Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI9 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9WMX2","evidenceCode":"ECO:0000250"}]} |
Chain | Residue | Details |