5FNT

Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1614

Chain	Residue
A	ASN414
A	0PL1615
A	HOH2041

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site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 0PL A 1615

Chain	Residue
A	PHE478
A	ARG483
A	SER508
A	GLY509
A	TYR525
A	GLN530
A	SER555
A	ALA556
A	TYR572
A	SER602
A	GLY603
A	CL1614
A	HOH2095
A	TYR334
A	SER363
A	GLY364
A	ASN382
A	ARG415
A	ILE461

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Sensor for electrophilic agents => ECO:0000269|PubMed:20498371

Chain	Residue	Details
A	CYS434

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: S-cGMP-cysteine => ECO:0000269|PubMed:20498371

Chain	Residue	Details
A	CYS434

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: S-(2-succinyl)cysteine => ECO:0000269|PubMed:22014577

Chain	Residue	Details
A	CYS613

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