5FM2

Crystal structure of hyper-phosphorylated RET kinase domain with (proximal) juxtamembrane segment

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PTR A 809

Chain	Residue
A	ALA807
A	LYS808
A	GLY810
A	VAL882
A	ALA883
A	GLU884
A	GLY885

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SEP A 909

Chain	Residue
A	LEU895
A	ARG897
A	LYS907
A	ARG908
A	GLN910
A	PTR928
A	ARG873
A	GLY894

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PTR A 928

Chain	Residue
A	ARG873
A	ARG897
A	SEP909
A	GLY911
A	MET918
A	SER922
A	HIS926
A	ILE927
A	THR929
A	SER932

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PP1 A 2012

Chain	Residue
A	LEU730
A	PHE735
A	VAL738
A	ALA756
A	LYS758
A	GLU775
A	VAL804
A	GLU805
A	ALA807
A	LEU881
A	SER891

---

site_id	AC5
Number of Residues	8
Details	Binding site for Ligand PTR A 905 bound to SER A 904

Chain	Residue
A	PRO720
A	ASN723
A	HIS745
A	HIS745
A	ASP903
A	SER904
A	VAL906
A	LYS907

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	29
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGEFGKVVkAtafhlkgragytt.....VAVK

Chain	Residue	Details
A	LEU730-LYS758

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. LVHrDLAARNILV

Chain	Residue	Details
A	LEU870-VAL882

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24560924","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4CKI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24560924","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20117004","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2X2M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Site: {"description":"Breakpoint for translocation to form PCM1-RET; RET-CCDC6; RET-GOLGA5; RET-TRIM24 and RET-TRIM33 oncogenes","evidences":[{"source":"PubMed","id":"10439047","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10980597","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2406025","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2734021","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"14711813","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"14711813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16928683","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24560924","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"14711813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16928683","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20117004","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24560924","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28846099","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"14711813","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24560924","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---