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5FL6

Three dimensional structure of human carbonic anhydrase IX in complex with 5-(1-(4-Methylphenyl)-1H-1,2,3-triazol-4-yl)thiophene-2- sulfonamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0004089molecular_functioncarbonate dehydratase activity
A0008270molecular_functionzinc ion binding
B0004089molecular_functioncarbonate dehydratase activity
B0008270molecular_functionzinc ion binding
C0004089molecular_functioncarbonate dehydratase activity
C0008270molecular_functionzinc ion binding
D0004089molecular_functioncarbonate dehydratase activity
D0008270molecular_functionzinc ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1260
ChainResidue
AHIS94
AHIS96
AHIS119
AY0R268

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE Y0R A 268
ChainResidue
ATHR200
ATHR201
ATRP210
AZN1260
AGOL1261
AHOH2364
AGLN92
AHIS94
AHIS96
AHIS119
ALEU199

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL A 1261
ChainResidue
AASN66
AHIS68
ASER69
AGLN71
AGLN92
AHIS94
ATHR201
AY0R268
AHOH2139

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1260
ChainResidue
BHIS94
BHIS96
BHIS119
BY0R269

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE Y0R B 269
ChainResidue
BGLN92
BHIS94
BHIS96
BHIS119
BVAL130
BLEU199
BTHR200
BTHR201
BTRP210
BZN1260
BGOL1261

site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL B 1261
ChainResidue
BASN66
BHIS68
BSER69
BGLN71
BGLN92
BHIS94
BY0R269
BHOH2004
BHOH2273

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 1260
ChainResidue
CHIS94
CHIS96
CHIS119
CY0R267

site_idAC8
Number of Residues14
DetailsBINDING SITE FOR RESIDUE Y0R C 267
ChainResidue
AHOH2277
CGLN92
CHIS94
CHIS96
CHIS119
CVAL121
CVAL130
CLEU134
CLEU199
CTHR200
CTHR201
CTRP210
CZN1260
CHOH2118

site_idAC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE GOL C 1261
ChainResidue
CASN66
CHIS68
CSER69
CGLN71
CGLN92
CHIS94
CTHR201
CHOH2003
CHOH2187
CHOH2231

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 1260
ChainResidue
DHIS94
DHIS96
DHIS119
DY0R266

site_idBC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE Y0R D 266
ChainResidue
DGLN92
DHIS94
DHIS96
DHIS119
DVAL121
DVAL130
DLEU199
DTHR200
DTHR201
DTRP210
DZN1260
DGOL1261

site_idBC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL D 1261
ChainResidue
DHOH2005
DASN66
DHIS68
DSER69
DGLN71
DGLN92
DHIS94
DY0R266

site_idBC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ACY D 1262
ChainResidue
BSER187
BHOH2282
DARG35
DPRO248
DLEU249
DASN250
DHOH2227

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ACY B 1263
ChainResidue
BHOH2254
DARG27
DPHE28
DASN250

Functional Information from PROSITE/UniProt
site_idPS00162
Number of Residues17
DetailsALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVeghrFpaEIHVV
ChainResidueDetails
ASER105-VAL121

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsActive site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"19805286","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18703501","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19805286","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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