5FKN
TetR(D) T103A mutant in complex with anhydrotetracycline and magnesium, P4(3)2(1)2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE TDC A 1209 |
| Chain | Residue |
| A | HIS64 |
| A | SER138 |
| A | MG1210 |
| A | HOH2083 |
| A | HOH2084 |
| A | HOH2085 |
| A | HOH2090 |
| A | HOH2136 |
| B | LEU174 |
| B | MET177 |
| A | SER67 |
| A | ASN82 |
| A | PHE86 |
| A | HIS100 |
| A | ARG104 |
| A | PRO105 |
| A | VAL113 |
| A | GLN116 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1210 |
| Chain | Residue |
| A | HIS100 |
| A | TDC1209 |
| A | HOH2083 |
| A | HOH2084 |
| A | HOH2085 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1211 |
| Chain | Residue |
| A | GLU7 |
| A | ARG62 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1212 |
| Chain | Residue |
| A | ARG3 |
| A | SER74 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 1213 |
| Chain | Residue |
| A | ARG3 |
| A | LEU4 |
| A | GLN76 |
| A | ARG80 |
| A | HOH2130 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 1214 |
| Chain | Residue |
| A | ASN5 |
| A | ARG6 |
| A | GLU7 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 1215 |
| Chain | Residue |
| A | THR26 |
| A | THR27 |
| A | HOH2025 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE TDC B 1209 |
| Chain | Residue |
| A | HOH2120 |
| B | HIS64 |
| B | SER67 |
| B | ASN82 |
| B | PHE86 |
| B | HIS100 |
| B | ARG104 |
| B | PRO105 |
| B | THR112 |
| B | VAL113 |
| B | GLN116 |
| B | ILE134 |
| B | MG1210 |
| B | HOH2068 |
| B | HOH2069 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1210 |
| Chain | Residue |
| A | HOH2118 |
| A | HOH2120 |
| B | HIS100 |
| B | TDC1209 |
| B | HOH2068 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1211 |
| Chain | Residue |
| B | GLU7 |
| B | GLU58 |
| B | ARG62 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 1212 |
| Chain | Residue |
| B | ARG3 |
| B | SER74 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL B 1213 |
| Chain | Residue |
| B | LEU4 |
| B | GLN76 |
| B | ARG80 |
| B | HOH2091 |
| site_id | BC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1214 |
| Chain | Residue |
| B | ASN5 |
| B | GLU7 |
| B | HOH2003 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1215 |
| Chain | Residue |
| B | THR26 |
| B | THR27 |
| B | HOH2019 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1216 |
| Chain | Residue |
| A | ARG88 |
| B | LYS33 |
Functional Information from PROSITE/UniProt
| site_id | PS01081 |
| Number of Residues | 32 |
| Details | HTH_TETR_1 TetR-type HTH domain signature. GIdglTTrkLaqklgIEqPtLYwHVkNKralL |
| Chain | Residue | Details |
| A | GLY21-LEU52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 120 |
| Details | Domain: {"description":"HTH tetR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 38 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00335","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8153629","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2TRT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
