Loading
PDBj
English日本語简体中文繁體中文한국어
✖
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5FIB

Open form of murine Acid Sphingomyelinase

Functional Information from GO Data
ChainGOidnamespacecontents
A0001778biological_processplasma membrane repair
A0004767molecular_functionsphingomyelin phosphodiesterase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005764cellular_componentlysosome
A0005768cellular_componentendosome
A0005811cellular_componentlipid droplet
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006672biological_processceramide metabolic process
A0006685biological_processsphingomyelin catabolic process
A0008203biological_processcholesterol metabolic process
A0008270molecular_functionzinc ion binding
A0009410biological_processresponse to xenobiotic stimulus
A0009615biological_processresponse to virus
A0010212biological_processresponse to ionizing radiation
A0016787molecular_functionhydrolase activity
A0016798molecular_functionhydrolase activity, acting on glycosyl bonds
A0023021biological_processtermination of signal transduction
A0033344biological_processcholesterol efflux
A0034340biological_processresponse to type I interferon
A0034480molecular_functionphosphatidylcholine phospholipase C activity
A0034612biological_processresponse to tumor necrosis factor
A0034644biological_processcellular response to UV
A0036019cellular_componentendolysosome
A0042060biological_processwound healing
A0042220biological_processresponse to cocaine
A0042599cellular_componentlamellar body
A0043065biological_processpositive regulation of apoptotic process
A0043409biological_processnegative regulation of MAPK cascade
A0045807biological_processpositive regulation of endocytosis
A0046513biological_processceramide biosynthetic process
A0046598biological_processpositive regulation of viral entry into host cell
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0061750molecular_functionacid sphingomyelin phosphodiesterase activity
A0070269biological_processpyroptotic inflammatory response
A0070555biological_processresponse to interleukin-1
A0071277biological_processcellular response to calcium ion
B0001778biological_processplasma membrane repair
B0004767molecular_functionsphingomyelin phosphodiesterase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005764cellular_componentlysosome
B0005768cellular_componentendosome
B0005811cellular_componentlipid droplet
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006672biological_processceramide metabolic process
B0006685biological_processsphingomyelin catabolic process
B0008203biological_processcholesterol metabolic process
B0008270molecular_functionzinc ion binding
B0009410biological_processresponse to xenobiotic stimulus
B0009615biological_processresponse to virus
B0010212biological_processresponse to ionizing radiation
B0016787molecular_functionhydrolase activity
B0016798molecular_functionhydrolase activity, acting on glycosyl bonds
B0023021biological_processtermination of signal transduction
B0033344biological_processcholesterol efflux
B0034340biological_processresponse to type I interferon
B0034480molecular_functionphosphatidylcholine phospholipase C activity
B0034612biological_processresponse to tumor necrosis factor
B0034644biological_processcellular response to UV
B0036019cellular_componentendolysosome
B0042060biological_processwound healing
B0042220biological_processresponse to cocaine
B0042599cellular_componentlamellar body
B0043065biological_processpositive regulation of apoptotic process
B0043409biological_processnegative regulation of MAPK cascade
B0045807biological_processpositive regulation of endocytosis
B0046513biological_processceramide biosynthetic process
B0046598biological_processpositive regulation of viral entry into host cell
B0046718biological_processsymbiont entry into host cell
B0046872molecular_functionmetal ion binding
B0061750molecular_functionacid sphingomyelin phosphodiesterase activity
B0070269biological_processpyroptotic inflammatory response
B0070555biological_processresponse to interleukin-1
B0071277biological_processcellular response to calcium ion
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27435900","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FIC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HQN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PDB","id":"5FI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FIC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HQN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsSite: {"description":"Cleavage; by CASP7","evidences":[{"source":"PubMed","id":"35705808","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P17405","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00415","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27435900","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FIB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00415","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27435900","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HQN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00415","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"27435900","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FI9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FIB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FIC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HQN","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

PDB statisticsPDBj update infoContact PDBjnumon