5FHN

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with (S)-2-Amino-3-(5-(2-(3-methylbenzyl)-2H-tetrazol-5-yl)-3-hydroxyisoxazol-4-yl)propanoic acid at 1.6 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 301

Chain	Residue
A	SER140
A	LYS144
A	ARG148
A	HOH424
A	HOH432
A	HOH436
A	HOH446
A	HOH504

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site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 302

Chain	Residue
A	GLU13
A	THR173
A	THR174
A	ALA175
A	HOH428
A	HOH557
A	HOH593
A	LEU12

---

site_id	AC3
Number of Residues	8
Details	binding site for residue GOL A 303

Chain	Residue
A	SER123
A	ALA124
A	GLY212
A	GLY213
A	LEU215
A	HOH401
A	HOH414
A	HOH579

---

site_id	AC4
Number of Residues	3
Details	binding site for residue ACT A 304

Chain	Residue
A	ASP139
A	SER168
A	HOH590

---

site_id	AC5
Number of Residues	18
Details	binding site for residue 5XO A 305

Chain	Residue
A	SER14
A	TYR16
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	GLY141
A	SER142
A	THR143
A	LEU192
A	GLU193
A	THR195
A	MET196
A	TYR220
A	TRP255
A	HOH441
A	HOH470

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 306

Chain	Residue
A	MET107
A	SER108
A	LYS251
A	HOH409
A	HOH421

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
A	THR91
A	ARG96
A	SER142
A	THR143
A	GLU193

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
A	ARG148
A	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3

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