5FFV
Crystal structure of the bromodomain of human BRPF1 in complex with H3K14ac histone peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 801 |
| Chain | Residue |
| A | PRO663 |
| A | ASP691 |
| A | ARG733 |
| A | GLU737 |
| A | HOH977 |
| B | ARG730 |
| B | ARG734 |
| B | HOH938 |
| B | HOH995 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 802 |
| Chain | Residue |
| A | THR712 |
| A | ILE713 |
| A | HOH911 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 801 |
| Chain | Residue |
| B | THR677 |
| B | ASN681 |
| B | HOH902 |
| B | HOH910 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. GniFsepvPlsevp..DYLdhIkkpMdfftMkqnleayr..Ylnfddfeedfnl.IvsNClkY |
| Chain | Residue | Details |
| A | GLY650-TYR707 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| C | LYS9 | |
| D | LYS9 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| C | SER10 | |
| D | SER10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| C | THR11 | |
| D | THR11 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| C | ALY14 | |
| D | ALY14 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:15345777, ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| C | ARG17 | |
| D | ARG17 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| C | LYS18 | |
| D | LYS18 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | LIPID: N6-decanoyllysine => ECO:0000269|PubMed:35939806 |
| Chain | Residue | Details |
| C | LYS18 | |
| D | LYS18 |
