5FF9
Noroxomaritidine/Norcraugsodine Reductase in Complex with NADP+ and tyramine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0009820 | biological_process | alkaloid metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0009820 | biological_process | alkaloid metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0009820 | biological_process | alkaloid metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0009820 | biological_process | alkaloid metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue NAP A 301 |
| Chain | Residue |
| A | GLY32 |
| A | ASP82 |
| A | VAL83 |
| A | ASN110 |
| A | GLY112 |
| A | ILE160 |
| A | SER161 |
| A | SER162 |
| A | TYR175 |
| A | LYS179 |
| A | PRO205 |
| A | THR34 |
| A | GLY206 |
| A | ALA207 |
| A | ILE208 |
| A | THR210 |
| A | GLY212 |
| A | THR213 |
| A | HOH403 |
| A | LYS35 |
| A | GLY36 |
| A | ILE37 |
| A | SER56 |
| A | ARG57 |
| A | ASN58 |
| A | CYS81 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | ASN183 |
| A | ARG187 |
| A | HOH402 |
| site_id | AC3 |
| Number of Residues | 40 |
| Details | binding site for residue NAP B 301 |
| Chain | Residue |
| B | GLY32 |
| B | THR34 |
| B | LYS35 |
| B | GLY36 |
| B | ILE37 |
| B | SER56 |
| B | ARG57 |
| B | ASN58 |
| B | CYS81 |
| B | ASP82 |
| B | VAL83 |
| B | ASN110 |
| B | GLY112 |
| B | VAL133 |
| B | ILE160 |
| B | SER161 |
| B | SER162 |
| B | TYR175 |
| B | LYS179 |
| B | PRO205 |
| B | GLY206 |
| B | ALA207 |
| B | ILE208 |
| B | THR210 |
| B | PRO211 |
| B | GLY212 |
| B | THR213 |
| B | AEF302 |
| B | HOH428 |
| B | HOH435 |
| B | HOH448 |
| B | HOH459 |
| B | HOH462 |
| B | HOH464 |
| B | HOH487 |
| B | HOH500 |
| B | HOH511 |
| B | HOH513 |
| B | HOH541 |
| B | HOH547 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue AEF B 302 |
| Chain | Residue |
| B | TYR114 |
| B | ILE169 |
| B | TYR175 |
| B | GLU226 |
| B | NAP301 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 303 |
| Chain | Residue |
| B | ARG86 |
| B | HOH425 |
| B | HOH454 |
| D | THR123 |
| D | ALA124 |
| D | HOH477 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 304 |
| Chain | Residue |
| B | GLN166 |
| B | ASN183 |
| B | ARG187 |
| B | VAL260 |
| B | HOH406 |
| B | HOH415 |
| D | SO4303 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 305 |
| Chain | Residue |
| B | ARG57 |
| B | PHE129 |
| B | HOH402 |
| B | HOH469 |
| B | HOH487 |
| B | HOH490 |
| site_id | AC8 |
| Number of Residues | 26 |
| Details | binding site for residue NAP C 301 |
| Chain | Residue |
| C | ARG57 |
| C | ASN58 |
| C | CYS81 |
| C | ASP82 |
| C | VAL83 |
| C | ASN110 |
| C | GLY112 |
| C | ILE160 |
| C | SER161 |
| C | SER162 |
| C | TYR175 |
| C | LYS179 |
| C | GLY206 |
| C | ALA207 |
| C | ILE208 |
| C | THR210 |
| C | PRO211 |
| C | GLY212 |
| C | THR213 |
| C | HOH415 |
| C | GLY32 |
| C | THR34 |
| C | LYS35 |
| C | GLY36 |
| C | ILE37 |
| C | SER56 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue AEF D 301 |
| Chain | Residue |
| D | SER162 |
| D | CYS163 |
| D | HIS172 |
| D | GLY206 |
| D | HOH405 |
| D | HOH508 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 302 |
| Chain | Residue |
| D | GLY32 |
| D | SER56 |
| D | ARG57 |
| D | ALA111 |
| D | HOH402 |
| D | HOH482 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 D 303 |
| Chain | Residue |
| B | SO4304 |
| D | GLN166 |
| D | ASN183 |
| D | ARG187 |
| D | VAL260 |
| D | HOH411 |
| site_id | AD3 |
| Number of Residues | 10 |
| Details | binding site for Ligand GLN B 67 bound to ASN D 58 |
| Chain | Residue |
| B | ARG63 |
| B | LYS64 |
| B | CYS65 |
| B | LEU66 |
| B | GLU68 |
| B | TRP69 |
| B | GLU70 |
| B | ASN71 |
| D | ASN58 |
| D | GLU61 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SccaqiaipgHsiYSSTKGAInQLTrNLA |
| Chain | Residue | Details |
| A | SER162-ALA190 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 56 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27252378","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FEU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FF9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FFF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27252378","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FF9","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
