5FEW

HydE from T. maritima in complex with S-adenosyl-L-cysteine (final product)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0042364	biological_process	water-soluble vitamin biosynthetic process
A	0044272	biological_process	sulfur compound biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
A	0051539	molecular_function	4 iron, 4 sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SF4 A 401

Chain	Residue
A	CYS63
A	CYS67
A	CYS70
A	MET409
A	SAH411

---

site_id	AC2
Number of Residues	18
Details	binding site for residue CPS A 402

Chain	Residue
A	GLY277
A	GLU280
A	ARG284
A	MET324
A	LEU330
A	CPS405
A	CPS406
A	HOH559
A	HOH610
A	HOH614
A	HOH680
A	HOH719
A	HOH771
A	HOH896
A	GLN98
A	PHE99
A	GLY100
A	PRO276

---

site_id	AC3
Number of Residues	14
Details	binding site for residue CPS A 403

Chain	Residue
A	LYS37
A	ASP40
A	LYS170
A	ARG284
A	SER297
A	LYS315
A	ASP316
A	THR317
A	HOH586
A	HOH594
A	HOH615
A	HOH649
A	HOH718
A	HOH844

---

site_id	AC4
Number of Residues	9
Details	binding site for residue CPS A 404

Chain	Residue
A	ARG29
A	GLU33
A	THR247
A	LEU250
A	CPS405
A	HOH511
A	HOH644
A	HOH697
A	HOH918

---

site_id	AC5
Number of Residues	12
Details	binding site for residue CPS A 405

Chain	Residue
A	ARG29
A	LYS315
A	THR317
A	ALA318
A	CPS402
A	CPS404
A	CPS406
A	HOH518
A	HOH602
A	HOH636
A	HOH650
A	HOH734

---

site_id	AC6
Number of Residues	17
Details	binding site for residue CPS A 406

Chain	Residue
A	LYS128
A	PRO321
A	MET324
A	LYS325
A	GLU328
A	TRP338
A	CPS402
A	CPS405
A	HOH574
A	HOH646
A	HOH703
A	HOH717
A	HOH803
A	HOH870
A	HOH902
A	HOH914
A	HOH921

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL A 407

Chain	Residue
A	ARG54
A	THR134
A	ARG155

---

site_id	AC8
Number of Residues	12
Details	binding site for residue MET A 409

Chain	Residue
A	SER108
A	SER136
A	ARG180
A	TYR303
A	LEU305
A	SF4401
A	5X8410
A	SAH411
A	HOH555
A	HOH571
A	HOH592
A	HOH654

---

site_id	AC9
Number of Residues	22
Details	binding site for residue 5X8 A 410

Chain	Residue
A	ALA270
A	LEU305
A	TYR306
A	CL408
A	MET409
A	SAH411
A	41K412
A	HOH521
A	HOH622
A	HOH654
A	HOH679
A	HOH694
A	HOH731
A	TYR69
A	GLN107
A	ARG159
A	GLU161
A	MET199
A	PRO229
A	ILE231
A	THR268
A	THR269

---

site_id	AD1
Number of Residues	20
Details	binding site for residue SAH A 411

Chain	Residue
A	TYR69
A	SER108
A	SER136
A	ARG159
A	GLU161
A	ARG180
A	MET199
A	PRO229
A	ILE231
A	TYR303
A	LEU305
A	TYR306
A	SF4401
A	MET409
A	5X8410
A	HOH555
A	HOH571
A	HOH592
A	HOH654
A	HOH694

---

site_id	AD2
Number of Residues	14
Details	binding site for residues CL A 408 and 41K A 412

Chain	Residue
A	ILE56
A	GLN107
A	ARG159
A	THR268
A	THR269
A	ALA270
A	MET291
A	TYR306
A	5X8410
A	HOH521
A	HOH622
A	HOH679
A	HOH706
A	HOH731

---

Functional Information from PROSITE/UniProt

site_id	PS00216
Number of Residues	18
Details	SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. VMKMIELLGRKpgrdwgG

Chain	Residue	Details
A	VAL323-GLY340

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	219
Details	Domain: {"description":"Radical SAM core","evidences":[{"source":"PROSITE-ProRule","id":"PRU01266","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR004762-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16137685","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18400755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19706452","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IIX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PIRSR","id":"PIRSR004762-1","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16137685","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3CIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IIX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IIZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JYE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PDB","id":"3CIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JYE","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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