5FEW
HydE from T. maritima in complex with S-adenosyl-L-cysteine (final product)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018130 | biological_process | obsolete heterocycle biosynthetic process |
| A | 0042364 | biological_process | water-soluble vitamin biosynthetic process |
| A | 0044271 | biological_process | obsolete cellular nitrogen compound biosynthetic process |
| A | 0044272 | biological_process | sulfur compound biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051537 | molecular_function | 2 iron, 2 sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
| A | 1901362 | biological_process | obsolete organic cyclic compound biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue SF4 A 401 |
| Chain | Residue |
| A | CYS63 |
| A | CYS67 |
| A | CYS70 |
| A | MET409 |
| A | SAH411 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue CPS A 402 |
| Chain | Residue |
| A | GLY277 |
| A | GLU280 |
| A | ARG284 |
| A | MET324 |
| A | LEU330 |
| A | CPS405 |
| A | CPS406 |
| A | HOH559 |
| A | HOH610 |
| A | HOH614 |
| A | HOH680 |
| A | HOH719 |
| A | HOH771 |
| A | HOH896 |
| A | GLN98 |
| A | PHE99 |
| A | GLY100 |
| A | PRO276 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | binding site for residue CPS A 403 |
| Chain | Residue |
| A | LYS37 |
| A | ASP40 |
| A | LYS170 |
| A | ARG284 |
| A | SER297 |
| A | LYS315 |
| A | ASP316 |
| A | THR317 |
| A | HOH586 |
| A | HOH594 |
| A | HOH615 |
| A | HOH649 |
| A | HOH718 |
| A | HOH844 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue CPS A 404 |
| Chain | Residue |
| A | ARG29 |
| A | GLU33 |
| A | THR247 |
| A | LEU250 |
| A | CPS405 |
| A | HOH511 |
| A | HOH644 |
| A | HOH697 |
| A | HOH918 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue CPS A 405 |
| Chain | Residue |
| A | ARG29 |
| A | LYS315 |
| A | THR317 |
| A | ALA318 |
| A | CPS402 |
| A | CPS404 |
| A | CPS406 |
| A | HOH518 |
| A | HOH602 |
| A | HOH636 |
| A | HOH650 |
| A | HOH734 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | binding site for residue CPS A 406 |
| Chain | Residue |
| A | LYS128 |
| A | PRO321 |
| A | MET324 |
| A | LYS325 |
| A | GLU328 |
| A | TRP338 |
| A | CPS402 |
| A | CPS405 |
| A | HOH574 |
| A | HOH646 |
| A | HOH703 |
| A | HOH717 |
| A | HOH803 |
| A | HOH870 |
| A | HOH902 |
| A | HOH914 |
| A | HOH921 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 407 |
| Chain | Residue |
| A | ARG54 |
| A | THR134 |
| A | ARG155 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | binding site for residue MET A 409 |
| Chain | Residue |
| A | SER108 |
| A | SER136 |
| A | ARG180 |
| A | TYR303 |
| A | LEU305 |
| A | SF4401 |
| A | 5X8410 |
| A | SAH411 |
| A | HOH555 |
| A | HOH571 |
| A | HOH592 |
| A | HOH654 |
| site_id | AC9 |
| Number of Residues | 22 |
| Details | binding site for residue 5X8 A 410 |
| Chain | Residue |
| A | ALA270 |
| A | LEU305 |
| A | TYR306 |
| A | CL408 |
| A | MET409 |
| A | SAH411 |
| A | 41K412 |
| A | HOH521 |
| A | HOH622 |
| A | HOH654 |
| A | HOH679 |
| A | HOH694 |
| A | HOH731 |
| A | TYR69 |
| A | GLN107 |
| A | ARG159 |
| A | GLU161 |
| A | MET199 |
| A | PRO229 |
| A | ILE231 |
| A | THR268 |
| A | THR269 |
| site_id | AD1 |
| Number of Residues | 20 |
| Details | binding site for residue SAH A 411 |
| Chain | Residue |
| A | TYR69 |
| A | SER108 |
| A | SER136 |
| A | ARG159 |
| A | GLU161 |
| A | ARG180 |
| A | MET199 |
| A | PRO229 |
| A | ILE231 |
| A | TYR303 |
| A | LEU305 |
| A | TYR306 |
| A | SF4401 |
| A | MET409 |
| A | 5X8410 |
| A | HOH555 |
| A | HOH571 |
| A | HOH592 |
| A | HOH654 |
| A | HOH694 |
| site_id | AD2 |
| Number of Residues | 14 |
| Details | binding site for residues CL A 408 and 41K A 412 |
| Chain | Residue |
| A | ILE56 |
| A | GLN107 |
| A | ARG159 |
| A | THR268 |
| A | THR269 |
| A | ALA270 |
| A | MET291 |
| A | TYR306 |
| A | 5X8410 |
| A | HOH521 |
| A | HOH622 |
| A | HOH679 |
| A | HOH706 |
| A | HOH731 |
Functional Information from PROSITE/UniProt
| site_id | PS00216 |
| Number of Residues | 18 |
| Details | SUGAR_TRANSPORT_1 Sugar transport proteins signature 1. VMKMIELLGRKpgrdwgG |
| Chain | Residue | Details |
| A | VAL323-GLY340 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000255|PIRSR:PIRSR004762-1, ECO:0000269|PubMed:16137685, ECO:0000269|PubMed:18400755, ECO:0000269|PubMed:19706452, ECO:0007744|PDB:3CIW, ECO:0007744|PDB:3CIX, ECO:0007744|PDB:3IIX |
| Chain | Residue | Details |
| A | CYS63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|PIRSR:PIRSR004762-1, ECO:0000269|PubMed:16137685, ECO:0007744|PDB:3CIW, ECO:0007744|PDB:3CIX, ECO:0007744|PDB:3IIX |
| Chain | Residue | Details |
| A | CYS67 | |
| A | CYS70 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:3CIX, ECO:0007744|PDB:3IIZ, ECO:0007744|PDB:4JXC, ECO:0007744|PDB:4JY8, ECO:0007744|PDB:4JY9, ECO:0007744|PDB:4JYE |
| Chain | Residue | Details |
| A | SER311 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:3CIX, ECO:0007744|PDB:4JY8, ECO:0007744|PDB:4JY9, ECO:0007744|PDB:4JYE |
| Chain | Residue | Details |
| A | SER319 | |
| A | SER322 |
