5FC7
Murine SMPDL3A in complex with sulfate (tetragonal)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004767 | molecular_function | sphingomyelin phosphodiesterase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006685 | biological_process | sphingomyelin catabolic process |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0008150 | biological_process | biological_process |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0009143 | biological_process | nucleoside triphosphate catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0160049 | biological_process | negative regulation of cGAS/STING signaling pathway |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26792860 |
| Chain | Residue | Details |
| A | ASP42 | |
| A | HIS44 | |
| A | ASP107 | |
| A | ASN148 | |
| A | HIS249 | |
| A | HIS290 | |
| A | HIS292 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:26792860 |
| Chain | Residue | Details |
| A | HIS111 | |
| A | HIS149 | |
| A | TYR257 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:26792860 |
| Chain | Residue | Details |
| A | ASN66 | |
| A | ASN128 | |
| A | ASN235 | |
| A | ASN353 | |
| A | ASN364 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN219 |
