5FAU

wild-type choline TMA lyase in complex with choline

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0016829	molecular_function	lyase activity
A	0016840	molecular_function	carbon-nitrogen lyase activity
A	0033265	molecular_function	choline binding
A	0042426	biological_process	choline catabolic process
A	0042803	molecular_function	protein homodimerization activity
A	0120525	molecular_function	choline trimethylamine lyase activity
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0016829	molecular_function	lyase activity
B	0016840	molecular_function	carbon-nitrogen lyase activity
B	0033265	molecular_function	choline binding
B	0042426	biological_process	choline catabolic process
B	0042803	molecular_function	protein homodimerization activity
B	0120525	molecular_function	choline trimethylamine lyase activity
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0016829	molecular_function	lyase activity
C	0016840	molecular_function	carbon-nitrogen lyase activity
C	0033265	molecular_function	choline binding
C	0042426	biological_process	choline catabolic process
C	0042803	molecular_function	protein homodimerization activity
C	0120525	molecular_function	choline trimethylamine lyase activity
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0016829	molecular_function	lyase activity
D	0016840	molecular_function	carbon-nitrogen lyase activity
D	0033265	molecular_function	choline binding
D	0042426	biological_process	choline catabolic process
D	0042803	molecular_function	protein homodimerization activity
D	0120525	molecular_function	choline trimethylamine lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue CHT A 901

Chain	Residue
A	TYR208
A	ASP216
A	GLY335
A	GLY488
A	CYS489
A	GLU491
A	TYR506
A	LEU698

---

site_id	AC2
Number of Residues	8
Details	binding site for residue GOL A 902

Chain	Residue
A	LEU536
A	ASN638
A	GLU639
A	LYS642
A	HOH1009
A	HOH1010
A	HOH1257
A	HIS519

---

site_id	AC3
Number of Residues	9
Details	binding site for residue CHT B 901

Chain	Residue
B	TYR208
B	ASP216
B	THR334
B	GLY488
B	CYS489
B	GLU491
B	THR502
B	TYR506
B	LEU698

---

site_id	AC4
Number of Residues	12
Details	binding site for residue GOL B 902

Chain	Residue
B	HIS677
B	GLU680
B	THR681
B	ARG684
B	ASN752
B	HOH1146
B	HOH1181
B	HOH1202
B	HOH1305
C	ILE478
C	GLU479
C	ARG482

---

site_id	AC5
Number of Residues	7
Details	binding site for residue GOL B 903

Chain	Residue
B	HIS519
B	LEU536
B	ASN638
B	GLU639
B	LYS642
B	HOH1107
B	HOH1259

---

site_id	AC6
Number of Residues	9
Details	binding site for residue CHT C 901

Chain	Residue
C	TYR208
C	ASP216
C	THR334
C	GLY488
C	CYS489
C	GLU491
C	THR502
C	TYR506
C	LEU698

---

site_id	AC7
Number of Residues	11
Details	binding site for residue GOL C 902

Chain	Residue
B	ILE478
B	GLU479
B	ARG482
C	HIS677
C	GLU680
C	THR681
C	ARG684
C	ASN752
C	HOH1157
C	HOH1262
C	HOH1428

---

site_id	AC8
Number of Residues	8
Details	binding site for residue GOL C 903

Chain	Residue
C	LEU517
C	HIS519
C	LEU536
C	ASN638
C	LYS642
C	HOH1115
C	HOH1118
C	HOH1192

---

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL C 904

Chain	Residue
C	LEU536
C	SER537
C	TYR539
C	VAL626
C	THR633
C	LEU634
C	ALA635
C	HOH1449

---

site_id	AD1
Number of Residues	8
Details	binding site for residue CHT D 901

Chain	Residue
D	TYR208
D	ASP216
D	GLY335
D	GLY488
D	CYS489
D	GLU491
D	TYR506
D	LEU698

---

site_id	AD2
Number of Residues	9
Details	binding site for residue GOL D 902

Chain	Residue
D	LEU517
D	HIS519
D	LEU536
D	ASN638
D	GLU639
D	LYS642
D	HOH1006
D	HOH1141
D	HOH1280

---

site_id	AD3
Number of Residues	8
Details	binding site for residue GOL D 903

Chain	Residue
D	GLY597
D	GLY598
D	ALA599
D	MET600
D	ASN602
D	HOH1020
D	GLY586
D	ARG592

---

Functional Information from PROSITE/UniProt

site_id	PS00850
Number of Residues	9
Details	GLY_RADICAL_1 Glycine radical domain signature. VvRVAGYSA

Chain	Residue	Details
A	VAL816-ALA824

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2632
Details	Domain: {"description":"PFL","evidences":[{"source":"PROSITE-ProRule","id":"PRU00887","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	484
Details	Domain: {"description":"Glycine radical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00493","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Cysteine radical intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_02058","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23151509","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24854437","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_02058","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24854437","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Glycine radical","evidences":[{"source":"HAMAP-Rule","id":"MF_02058","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23151509","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24854437","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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