5FAS
OXA-48 in complex with FPI-1523
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008658 | molecular_function | penicillin binding |
| A | 0008800 | molecular_function | beta-lactamase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017001 | biological_process | antibiotic catabolic process |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0071555 | biological_process | cell wall organization |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008658 | molecular_function | penicillin binding |
| B | 0008800 | molecular_function | beta-lactamase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0017001 | biological_process | antibiotic catabolic process |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0071555 | biological_process | cell wall organization |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue 5VR A 301 |
| Chain | Residue |
| A | ALA69 |
| A | ARG214 |
| A | ARG250 |
| A | HOH511 |
| A | HOH517 |
| A | SER70 |
| A | SER118 |
| A | VAL120 |
| A | LYS208 |
| A | THR209 |
| A | GLY210 |
| A | TYR211 |
| A | THR213 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 302 |
| Chain | Residue |
| A | ARG206 |
| B | ARG206 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CD A 303 |
| Chain | Residue |
| A | ASP143 |
| A | HOH448 |
| A | HOH606 |
| B | ASP143 |
| B | HOH488 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CD A 304 |
| Chain | Residue |
| A | GLU37 |
| A | HIS38 |
| A | GLU125 |
| A | GLU256 |
| A | CO307 |
| A | HOH572 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue CO A 305 |
| Chain | Residue |
| A | GLU147 |
| A | CO306 |
| A | HOH438 |
| B | HIS140 |
| B | GLU147 |
| B | HOH436 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CO A 306 |
| Chain | Residue |
| A | HIS140 |
| A | GLU147 |
| A | CO305 |
| A | HOH438 |
| B | GLU147 |
| B | HOH436 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue CO A 307 |
| Chain | Residue |
| A | HIS34 |
| A | GLU37 |
| A | GLU256 |
| A | CD304 |
| A | HOH572 |
| A | HOH613 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CO B 301 |
| Chain | Residue |
| B | HIS140 |
| B | HOH527 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue CO B 302 |
| Chain | Residue |
| A | HIS140 |
| A | HOH581 |
| A | HOH611 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CO B 303 |
| Chain | Residue |
| B | HIS34 |
| B | GLU37 |
| B | GLU256 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue CO B 305 |
| Chain | Residue |
| A | HIS178 |
| A | HOH648 |
| B | HIS90 |
Functional Information from PROSITE/UniProt
| site_id | PS00337 |
| Number of Residues | 11 |
| Details | BETA_LACTAMASE_D Beta-lactamase class-D active site. PaSTFKIPnSL |
| Chain | Residue | Details |
| A | PRO68-LEU78 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26731698","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31358584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32150407","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5FAS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P97","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P98","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P99","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6P9C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6V1O","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8RLA6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P13661","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PIRSR","id":"PIRSR602137-50","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19477418","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406838","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3HBR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WMC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
