5FAK
Crystal structure of Double Mutant S12T and N87T of Adenosine/Methylthioadenosine Phosphorylase from Schistosoma mansoni in complex with Adenine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0005634 | cellular_component | nucleus |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue ADE A 301 |
| Chain | Residue |
| A | ALA88 |
| A | HOH434 |
| A | HOH494 |
| A | CYS89 |
| A | GLY90 |
| A | PHE187 |
| A | VAL204 |
| A | ASN205 |
| A | THR229 |
| A | ASP230 |
| A | ASP232 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | GLY11 |
| A | THR12 |
| A | ARG54 |
| A | HIS55 |
| A | THR87 |
| A | ALA88 |
| A | THR207 |
| A | HOH406 |
| A | HOH494 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue ADE B 301 |
| Chain | Residue |
| B | ALA88 |
| B | CYS89 |
| B | GLY90 |
| B | PHE187 |
| B | VAL204 |
| B | ASN205 |
| B | THR229 |
| B | ASP232 |
| B | HOH440 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | GLY11 |
| B | THR12 |
| B | ARG54 |
| B | HIS55 |
| B | THR87 |
| B | ALA88 |
| B | THR207 |
| B | HOH422 |
| B | HOH439 |
| B | HOH458 |
| B | HOH473 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 C 301 |
| Chain | Residue |
| C | GLY11 |
| C | THR12 |
| C | ARG54 |
| C | HIS55 |
| C | THR87 |
| C | ALA88 |
| C | THR207 |
| C | HOH419 |
| C | HOH442 |
| C | HOH469 |
| C | HOH471 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue ADE D 301 |
| Chain | Residue |
| D | ALA88 |
| D | CYS89 |
| D | GLY90 |
| D | PHE187 |
| D | VAL204 |
| D | ASN205 |
| D | THR229 |
| D | ASP230 |
| D | ASP232 |
| D | HOH434 |
| D | HOH468 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 D 302 |
| Chain | Residue |
| D | GLY11 |
| D | THR12 |
| D | ARG54 |
| D | HIS55 |
| D | THR87 |
| D | ALA88 |
| D | THR207 |
| D | HOH409 |
| D | HOH468 |
| D | HOH503 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue ADE E 301 |
| Chain | Residue |
| E | ALA88 |
| E | CYS89 |
| E | GLY90 |
| E | PHE187 |
| E | VAL204 |
| E | ASN205 |
| E | THR229 |
| E | ASP230 |
| E | ASP232 |
| E | HOH452 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 E 302 |
| Chain | Residue |
| E | GLY11 |
| E | THR12 |
| E | ARG54 |
| E | HIS55 |
| E | THR87 |
| E | ALA88 |
| E | THR207 |
| E | HOH418 |
| E | HOH433 |
| E | HOH456 |
| site_id | AD1 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 F 301 |
| Chain | Residue |
| F | HOH403 |
| F | HOH434 |
| F | HOH453 |
| F | HOH502 |
| F | GLY11 |
| F | THR12 |
| F | ARG54 |
| F | HIS55 |
| F | THR87 |
| F | ALA88 |
| F | THR207 |
Functional Information from PROSITE/UniProt
| site_id | PS01240 |
| Number of Residues | 41 |
| Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LprhGkgHlIppseVnyrAn.VwAlkdlGcth.ILatTAcGSL |
| Chain | Residue | Details |
| A | LEU52-LEU92 |
