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Crystal structure of Double Mutant S12T and N87T of Adenosine/Methylthioadenosine Phosphorylase from Schistosoma mansoni in complex with Adenine

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006166biological_processpurine ribonucleoside salvage
A0009116biological_processnucleoside metabolic process
A0016757molecular_functionglycosyltransferase activity
A0016763molecular_functionpentosyltransferase activity
A0017061molecular_functionS-methyl-5-thioadenosine phosphorylase activity
A0019509biological_processL-methionine salvage from methylthioadenosine
B0003824molecular_functioncatalytic activity
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006166biological_processpurine ribonucleoside salvage
B0009116biological_processnucleoside metabolic process
B0016757molecular_functionglycosyltransferase activity
B0016763molecular_functionpentosyltransferase activity
B0017061molecular_functionS-methyl-5-thioadenosine phosphorylase activity
B0019509biological_processL-methionine salvage from methylthioadenosine
C0003824molecular_functioncatalytic activity
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006166biological_processpurine ribonucleoside salvage
C0009116biological_processnucleoside metabolic process
C0016757molecular_functionglycosyltransferase activity
C0016763molecular_functionpentosyltransferase activity
C0017061molecular_functionS-methyl-5-thioadenosine phosphorylase activity
C0019509biological_processL-methionine salvage from methylthioadenosine
D0003824molecular_functioncatalytic activity
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006166biological_processpurine ribonucleoside salvage
D0009116biological_processnucleoside metabolic process
D0016757molecular_functionglycosyltransferase activity
D0016763molecular_functionpentosyltransferase activity
D0017061molecular_functionS-methyl-5-thioadenosine phosphorylase activity
D0019509biological_processL-methionine salvage from methylthioadenosine
E0003824molecular_functioncatalytic activity
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006166biological_processpurine ribonucleoside salvage
E0009116biological_processnucleoside metabolic process
E0016757molecular_functionglycosyltransferase activity
E0016763molecular_functionpentosyltransferase activity
E0017061molecular_functionS-methyl-5-thioadenosine phosphorylase activity
E0019509biological_processL-methionine salvage from methylthioadenosine
F0003824molecular_functioncatalytic activity
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006166biological_processpurine ribonucleoside salvage
F0009116biological_processnucleoside metabolic process
F0016757molecular_functionglycosyltransferase activity
F0016763molecular_functionpentosyltransferase activity
F0017061molecular_functionS-methyl-5-thioadenosine phosphorylase activity
F0019509biological_processL-methionine salvage from methylthioadenosine
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue ADE A 301
ChainResidue
AALA88
AHOH434
AHOH494
ACYS89
AGLY90
APHE187
AVAL204
AASN205
ATHR229
AASP230
AASP232

site_idAC2
Number of Residues9
Detailsbinding site for residue SO4 A 302
ChainResidue
AGLY11
ATHR12
AARG54
AHIS55
ATHR87
AALA88
ATHR207
AHOH406
AHOH494

site_idAC3
Number of Residues9
Detailsbinding site for residue ADE B 301
ChainResidue
BALA88
BCYS89
BGLY90
BPHE187
BVAL204
BASN205
BTHR229
BASP232
BHOH440

site_idAC4
Number of Residues11
Detailsbinding site for residue SO4 B 302
ChainResidue
BGLY11
BTHR12
BARG54
BHIS55
BTHR87
BALA88
BTHR207
BHOH422
BHOH439
BHOH458
BHOH473

site_idAC5
Number of Residues11
Detailsbinding site for residue SO4 C 301
ChainResidue
CGLY11
CTHR12
CARG54
CHIS55
CTHR87
CALA88
CTHR207
CHOH419
CHOH442
CHOH469
CHOH471

site_idAC6
Number of Residues11
Detailsbinding site for residue ADE D 301
ChainResidue
DALA88
DCYS89
DGLY90
DPHE187
DVAL204
DASN205
DTHR229
DASP230
DASP232
DHOH434
DHOH468

site_idAC7
Number of Residues10
Detailsbinding site for residue SO4 D 302
ChainResidue
DGLY11
DTHR12
DARG54
DHIS55
DTHR87
DALA88
DTHR207
DHOH409
DHOH468
DHOH503

site_idAC8
Number of Residues10
Detailsbinding site for residue ADE E 301
ChainResidue
EALA88
ECYS89
EGLY90
EPHE187
EVAL204
EASN205
ETHR229
EASP230
EASP232
EHOH452

site_idAC9
Number of Residues10
Detailsbinding site for residue SO4 E 302
ChainResidue
EGLY11
ETHR12
EARG54
EHIS55
ETHR87
EALA88
ETHR207
EHOH418
EHOH433
EHOH456

site_idAD1
Number of Residues11
Detailsbinding site for residue SO4 F 301
ChainResidue
FHOH403
FHOH434
FHOH453
FHOH502
FGLY11
FTHR12
FARG54
FHIS55
FTHR87
FALA88
FTHR207

Functional Information from PROSITE/UniProt
site_idPS01240
Number of Residues41
DetailsPNP_MTAP_2 Purine and other phosphorylases family 2 signature. LprhGkgHlIppseVnyrAn.VwAlkdlGcth.ILatTAcGSL
ChainResidueDetails
ALEU52-LEU92

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PDB entries from 2024-08-07

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