5FAJ

Alanine Racemase from Streptomyces coelicolor A3(2) in complex with D-Cycloserine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0006522	biological_process	alanine metabolic process
A	0008784	molecular_function	alanine racemase activity
A	0009252	biological_process	peptidoglycan biosynthetic process
A	0016853	molecular_function	isomerase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	0030632	biological_process	D-alanine biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0005829	cellular_component	cytosol
B	0006522	biological_process	alanine metabolic process
B	0008784	molecular_function	alanine racemase activity
B	0009252	biological_process	peptidoglycan biosynthetic process
B	0016853	molecular_function	isomerase activity
B	0030170	molecular_function	pyridoxal phosphate binding
B	0030632	biological_process	D-alanine biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0005829	cellular_component	cytosol
C	0006522	biological_process	alanine metabolic process
C	0008784	molecular_function	alanine racemase activity
C	0009252	biological_process	peptidoglycan biosynthetic process
C	0016853	molecular_function	isomerase activity
C	0030170	molecular_function	pyridoxal phosphate binding
C	0030632	biological_process	D-alanine biosynthetic process
D	0003824	molecular_function	catalytic activity
D	0005829	cellular_component	cytosol
D	0006522	biological_process	alanine metabolic process
D	0008784	molecular_function	alanine racemase activity
D	0009252	biological_process	peptidoglycan biosynthetic process
D	0016853	molecular_function	isomerase activity
D	0030170	molecular_function	pyridoxal phosphate binding
D	0030632	biological_process	D-alanine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	binding site for residue DCS A 401

Chain	Residue
A	LYS46
A	PRO238
A	GLY239
A	ILE240
A	TYR374
A	HOH502
A	HOH505
A	HOH615
B	TYR283
B	TYR302
B	ALA330
A	TYR50
B	MET331
B	HOH534
B	HOH545
A	TRP96
A	ARG148
A	TRP179
A	HIS181
A	ASN221
A	SER222
A	ARG237

---

site_id	AC2
Number of Residues	8
Details	binding site for residue NA A 402

Chain	Residue
A	ALA142
A	ASP143
A	THR144
A	LEU146
A	SER180
A	HIS181
A	GLN196
A	CL403

---

site_id	AC3
Number of Residues	6
Details	binding site for residue CL A 403

Chain	Residue
A	KCX141
A	ASP143
A	ARG148
A	GLY149
A	GLY150
A	NA402

---

site_id	AC4
Number of Residues	20
Details	binding site for residue DCS B 401

Chain	Residue
A	TYR283
A	TYR302
A	ALA330
A	MET331
A	HOH530
A	HOH533
B	LYS46
B	TYR50
B	ARG148
B	TRP179
B	HIS181
B	ASN221
B	SER222
B	ARG237
B	PRO238
B	GLY239
B	ILE240
B	TYR374
B	HOH502
B	HOH556

---

site_id	AC5
Number of Residues	8
Details	binding site for residue NA B 402

Chain	Residue
B	ASP143
B	THR144
B	GLY145
B	LEU146
B	SER180
B	HIS181
B	GLN196
B	CL403

---

site_id	AC6
Number of Residues	7
Details	binding site for residue CL B 403

Chain	Residue
B	KCX141
B	ASP143
B	LEU146
B	ARG148
B	GLY149
B	GLY150
B	NA402

---

site_id	AC7
Number of Residues	3
Details	binding site for residue CL B 404

Chain	Residue
B	HIS286
B	SER311
B	SER312

---

site_id	AC8
Number of Residues	20
Details	binding site for residue DCS C 401

Chain	Residue
C	LYS46
C	TYR50
C	TRP96
C	ARG148
C	TRP179
C	HIS181
C	ASN221
C	SER222
C	ARG237
C	PRO238
C	GLY239
C	ILE240
C	TYR374
C	HOH513
C	HOH577
D	TYR283
D	TYR302
D	ALA330
D	MET331
D	HOH504

---

site_id	AC9
Number of Residues	8
Details	binding site for residue NA C 402

Chain	Residue
C	HIS181
C	GLN196
C	CL405
C	ASP143
C	THR144
C	GLY145
C	LEU146
C	SER180

---

site_id	AD1
Number of Residues	6
Details	binding site for residue NA C 403

Chain	Residue
C	HIS218
C	ILE219
C	ALA220
C	ALA231
C	HIS232
C	LEU235

---

site_id	AD2
Number of Residues	2
Details	binding site for residue NA C 404

Chain	Residue
C	HIS286
C	SER312

---

site_id	AD3
Number of Residues	6
Details	binding site for residue CL C 405

Chain	Residue
C	KCX141
C	ASP143
C	ARG148
C	GLY149
C	GLY150
C	NA402

---

site_id	AD4
Number of Residues	18
Details	binding site for residue DCS D 401

Chain	Residue
C	TYR283
C	TYR302
C	ALA330
C	MET331
D	LYS46
D	TYR50
D	TRP96
D	ARG148
D	TRP179
D	HIS181
D	ASN221
D	SER222
D	ARG237
D	PRO238
D	GLY239
D	ILE240
D	TYR374
D	HOH501

---

site_id	AD5
Number of Residues	3
Details	binding site for residue NA D 402

Chain	Residue
D	HIS286
D	SER311
D	SER312

---

site_id	AD6
Number of Residues	4
Details	binding site for residue CL D 403

Chain	Residue
D	KCX141
D	ARG148
D	GLY149
D	GLY150

---

Functional Information from PROSITE/UniProt

site_id	PS00395
Number of Residues	11
Details	ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKADAYGHG

Chain	Residue	Details
A	ALA43-GLY53

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor; specific for D-alanine","evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor; specific for L-alanine","evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---