5FAG
Alanine Racemase from Streptomyces coelicolor A3(2) with Bound Propionate Inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006522 | biological_process | alanine metabolic process |
| A | 0008784 | molecular_function | alanine racemase activity |
| A | 0009252 | biological_process | peptidoglycan biosynthetic process |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0030632 | biological_process | D-alanine biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006522 | biological_process | alanine metabolic process |
| B | 0008784 | molecular_function | alanine racemase activity |
| B | 0009252 | biological_process | peptidoglycan biosynthetic process |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0030632 | biological_process | D-alanine biosynthetic process |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006522 | biological_process | alanine metabolic process |
| C | 0008784 | molecular_function | alanine racemase activity |
| C | 0009252 | biological_process | peptidoglycan biosynthetic process |
| C | 0016853 | molecular_function | isomerase activity |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0030632 | biological_process | D-alanine biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006522 | biological_process | alanine metabolic process |
| D | 0008784 | molecular_function | alanine racemase activity |
| D | 0009252 | biological_process | peptidoglycan biosynthetic process |
| D | 0016853 | molecular_function | isomerase activity |
| D | 0030170 | molecular_function | pyridoxal phosphate binding |
| D | 0030632 | biological_process | D-alanine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue PLP A 401 |
| Chain | Residue |
| A | LYS46 |
| A | ILE240 |
| A | TYR374 |
| A | HOH600 |
| B | PPI501 |
| A | TYR50 |
| A | TRP96 |
| A | KCX141 |
| A | TRP179 |
| A | SER222 |
| A | ARG237 |
| A | PRO238 |
| A | GLY239 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | binding site for residue PPI A 402 |
| Chain | Residue |
| A | TYR283 |
| A | ALA330 |
| A | MET331 |
| A | HOH559 |
| A | HOH566 |
| B | LYS46 |
| B | TYR50 |
| B | ARG148 |
| B | PLP502 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | MET42 |
| A | ALA43 |
| A | VAL44 |
| A | PRO238 |
| A | GLY239 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue NA A 404 |
| Chain | Residue |
| A | ALA142 |
| A | ASP143 |
| A | THR144 |
| A | GLY145 |
| A | LEU146 |
| A | SER180 |
| A | HIS181 |
| A | GLN196 |
| A | HOH698 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue NO3 A 405 |
| Chain | Residue |
| A | ARG26 |
| A | ARG30 |
| A | ALA63 |
| A | ALA64 |
| A | HOH532 |
| A | HOH606 |
| C | ARG260 |
| C | ASP356 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue PPI B 501 |
| Chain | Residue |
| A | LYS46 |
| A | PLP401 |
| A | HOH600 |
| B | TYR283 |
| B | ALA330 |
| B | MET331 |
| B | HOH663 |
| B | HOH672 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 503 |
| Chain | Residue |
| B | SER282 |
| B | ALA326 |
| B | ARG328 |
| B | PHE334 |
| B | VAL335 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue NA B 504 |
| Chain | Residue |
| B | ASP143 |
| B | THR144 |
| B | GLY145 |
| B | LEU146 |
| B | SER180 |
| B | HIS181 |
| B | GLN196 |
| B | HOH606 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PPI B 505 |
| Chain | Residue |
| B | GLY154 |
| B | GLU158 |
| B | TYR206 |
| B | HOH812 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue PPI B 506 |
| Chain | Residue |
| B | TYR388 |
| B | GLU391 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue PPI B 507 |
| Chain | Residue |
| B | GLU208 |
| B | ARG217 |
| C | ARG166 |
| C | GLU169 |
| C | HOH505 |
| site_id | AD3 |
| Number of Residues | 8 |
| Details | binding site for residue NO3 B 508 |
| Chain | Residue |
| B | ARG26 |
| B | ARG30 |
| B | ALA63 |
| B | ALA64 |
| B | HOH733 |
| B | HOH776 |
| D | ARG260 |
| D | ASP356 |
| site_id | AD4 |
| Number of Residues | 9 |
| Details | binding site for residue PPI C 402 |
| Chain | Residue |
| C | TYR283 |
| C | TYR302 |
| C | ALA330 |
| C | MET331 |
| C | HOH501 |
| D | LYS46 |
| D | TYR374 |
| D | PLP502 |
| D | HOH725 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 403 |
| Chain | Residue |
| C | HIS218 |
| C | ILE219 |
| C | ALA220 |
| C | ALA231 |
| C | HIS232 |
| C | LEU235 |
| site_id | AD6 |
| Number of Residues | 8 |
| Details | binding site for residue PPI D 501 |
| Chain | Residue |
| C | LYS46 |
| C | PLP401 |
| C | HOH551 |
| D | TYR283 |
| D | ALA330 |
| D | MET331 |
| D | HOH636 |
| D | HOH664 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue PPI D 503 |
| Chain | Residue |
| D | TYR287 |
| D | THR324 |
| D | VAL325 |
| D | ALA326 |
| D | ASP337 |
| D | HOH692 |
| D | HOH709 |
| site_id | AD8 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide PLP B 502 and LYS B 46 |
| Chain | Residue |
| A | MET331 |
| A | ASP332 |
| A | PPI402 |
| A | HOH517 |
| B | VAL44 |
| B | VAL45 |
| B | ALA47 |
| B | ASP48 |
| B | ALA49 |
| B | TYR50 |
| B | GLY70 |
| B | ALA72 |
| B | TRP96 |
| B | KCX141 |
| B | TRP179 |
| B | HIS181 |
| B | ASN221 |
| B | SER222 |
| B | ARG237 |
| B | PRO238 |
| B | GLY239 |
| B | ILE240 |
| B | TYR374 |
| B | HOH664 |
| site_id | AD9 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide PLP C 401 and LYS C 46 |
| Chain | Residue |
| C | VAL44 |
| C | VAL45 |
| C | ALA47 |
| C | ASP48 |
| C | ALA49 |
| C | TYR50 |
| C | GLY70 |
| C | ALA72 |
| C | TRP96 |
| C | KCX141 |
| C | TRP179 |
| C | HIS181 |
| C | ASN221 |
| C | SER222 |
| C | ARG237 |
| C | PRO238 |
| C | GLY239 |
| C | ILE240 |
| C | TYR374 |
| C | HOH507 |
| C | HOH551 |
| D | ASP332 |
| D | PPI501 |
| site_id | AE1 |
| Number of Residues | 21 |
| Details | binding site for Di-peptide PLP D 502 and LYS D 46 |
| Chain | Residue |
| C | ASP332 |
| C | PPI402 |
| D | VAL44 |
| D | VAL45 |
| D | ALA47 |
| D | ASP48 |
| D | ALA49 |
| D | TYR50 |
| D | GLY70 |
| D | ALA72 |
| D | TRP96 |
| D | KCX141 |
| D | TRP179 |
| D | HIS181 |
| D | ASN221 |
| D | SER222 |
| D | ARG237 |
| D | PRO238 |
| D | GLY239 |
| D | ILE240 |
| D | TYR374 |
Functional Information from PROSITE/UniProt
| site_id | PS00395 |
| Number of Residues | 11 |
| Details | ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKADAYGHG |
| Chain | Residue | Details |
| A | ALA43-GLY53 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor; specific for D-alanine","evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor; specific for L-alanine","evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"HAMAP-Rule","id":"MF_01201","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
