5FAG
Alanine Racemase from Streptomyces coelicolor A3(2) with Bound Propionate Inhibitor
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0005829 | cellular_component | cytosol |
A | 0006522 | biological_process | alanine metabolic process |
A | 0008784 | molecular_function | alanine racemase activity |
A | 0009252 | biological_process | peptidoglycan biosynthetic process |
A | 0016853 | molecular_function | isomerase activity |
A | 0030170 | molecular_function | pyridoxal phosphate binding |
A | 0030632 | biological_process | D-alanine biosynthetic process |
B | 0003824 | molecular_function | catalytic activity |
B | 0005829 | cellular_component | cytosol |
B | 0006522 | biological_process | alanine metabolic process |
B | 0008784 | molecular_function | alanine racemase activity |
B | 0009252 | biological_process | peptidoglycan biosynthetic process |
B | 0016853 | molecular_function | isomerase activity |
B | 0030170 | molecular_function | pyridoxal phosphate binding |
B | 0030632 | biological_process | D-alanine biosynthetic process |
C | 0003824 | molecular_function | catalytic activity |
C | 0005829 | cellular_component | cytosol |
C | 0006522 | biological_process | alanine metabolic process |
C | 0008784 | molecular_function | alanine racemase activity |
C | 0009252 | biological_process | peptidoglycan biosynthetic process |
C | 0016853 | molecular_function | isomerase activity |
C | 0030170 | molecular_function | pyridoxal phosphate binding |
C | 0030632 | biological_process | D-alanine biosynthetic process |
D | 0003824 | molecular_function | catalytic activity |
D | 0005829 | cellular_component | cytosol |
D | 0006522 | biological_process | alanine metabolic process |
D | 0008784 | molecular_function | alanine racemase activity |
D | 0009252 | biological_process | peptidoglycan biosynthetic process |
D | 0016853 | molecular_function | isomerase activity |
D | 0030170 | molecular_function | pyridoxal phosphate binding |
D | 0030632 | biological_process | D-alanine biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | binding site for residue PLP A 401 |
Chain | Residue |
A | LYS46 |
A | ILE240 |
A | TYR374 |
A | HOH600 |
B | PPI501 |
A | TYR50 |
A | TRP96 |
A | KCX141 |
A | TRP179 |
A | SER222 |
A | ARG237 |
A | PRO238 |
A | GLY239 |
site_id | AC2 |
Number of Residues | 9 |
Details | binding site for residue PPI A 402 |
Chain | Residue |
A | TYR283 |
A | ALA330 |
A | MET331 |
A | HOH559 |
A | HOH566 |
B | LYS46 |
B | TYR50 |
B | ARG148 |
B | PLP502 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue NA A 403 |
Chain | Residue |
A | MET42 |
A | ALA43 |
A | VAL44 |
A | PRO238 |
A | GLY239 |
site_id | AC4 |
Number of Residues | 9 |
Details | binding site for residue NA A 404 |
Chain | Residue |
A | ALA142 |
A | ASP143 |
A | THR144 |
A | GLY145 |
A | LEU146 |
A | SER180 |
A | HIS181 |
A | GLN196 |
A | HOH698 |
site_id | AC5 |
Number of Residues | 8 |
Details | binding site for residue NO3 A 405 |
Chain | Residue |
A | ARG26 |
A | ARG30 |
A | ALA63 |
A | ALA64 |
A | HOH532 |
A | HOH606 |
C | ARG260 |
C | ASP356 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue PPI B 501 |
Chain | Residue |
A | LYS46 |
A | PLP401 |
A | HOH600 |
B | TYR283 |
B | ALA330 |
B | MET331 |
B | HOH663 |
B | HOH672 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue NA B 503 |
Chain | Residue |
B | SER282 |
B | ALA326 |
B | ARG328 |
B | PHE334 |
B | VAL335 |
site_id | AC8 |
Number of Residues | 8 |
Details | binding site for residue NA B 504 |
Chain | Residue |
B | ASP143 |
B | THR144 |
B | GLY145 |
B | LEU146 |
B | SER180 |
B | HIS181 |
B | GLN196 |
B | HOH606 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue PPI B 505 |
Chain | Residue |
B | GLY154 |
B | GLU158 |
B | TYR206 |
B | HOH812 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue PPI B 506 |
Chain | Residue |
B | TYR388 |
B | GLU391 |
site_id | AD2 |
Number of Residues | 5 |
Details | binding site for residue PPI B 507 |
Chain | Residue |
B | GLU208 |
B | ARG217 |
C | ARG166 |
C | GLU169 |
C | HOH505 |
site_id | AD3 |
Number of Residues | 8 |
Details | binding site for residue NO3 B 508 |
Chain | Residue |
B | ARG26 |
B | ARG30 |
B | ALA63 |
B | ALA64 |
B | HOH733 |
B | HOH776 |
D | ARG260 |
D | ASP356 |
site_id | AD4 |
Number of Residues | 9 |
Details | binding site for residue PPI C 402 |
Chain | Residue |
C | TYR283 |
C | TYR302 |
C | ALA330 |
C | MET331 |
C | HOH501 |
D | LYS46 |
D | TYR374 |
D | PLP502 |
D | HOH725 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue NA C 403 |
Chain | Residue |
C | HIS218 |
C | ILE219 |
C | ALA220 |
C | ALA231 |
C | HIS232 |
C | LEU235 |
site_id | AD6 |
Number of Residues | 8 |
Details | binding site for residue PPI D 501 |
Chain | Residue |
C | LYS46 |
C | PLP401 |
C | HOH551 |
D | TYR283 |
D | ALA330 |
D | MET331 |
D | HOH636 |
D | HOH664 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue PPI D 503 |
Chain | Residue |
D | TYR287 |
D | THR324 |
D | VAL325 |
D | ALA326 |
D | ASP337 |
D | HOH692 |
D | HOH709 |
site_id | AD8 |
Number of Residues | 24 |
Details | binding site for Di-peptide PLP B 502 and LYS B 46 |
Chain | Residue |
A | MET331 |
A | ASP332 |
A | PPI402 |
A | HOH517 |
B | VAL44 |
B | VAL45 |
B | ALA47 |
B | ASP48 |
B | ALA49 |
B | TYR50 |
B | GLY70 |
B | ALA72 |
B | TRP96 |
B | KCX141 |
B | TRP179 |
B | HIS181 |
B | ASN221 |
B | SER222 |
B | ARG237 |
B | PRO238 |
B | GLY239 |
B | ILE240 |
B | TYR374 |
B | HOH664 |
site_id | AD9 |
Number of Residues | 23 |
Details | binding site for Di-peptide PLP C 401 and LYS C 46 |
Chain | Residue |
C | VAL44 |
C | VAL45 |
C | ALA47 |
C | ASP48 |
C | ALA49 |
C | TYR50 |
C | GLY70 |
C | ALA72 |
C | TRP96 |
C | KCX141 |
C | TRP179 |
C | HIS181 |
C | ASN221 |
C | SER222 |
C | ARG237 |
C | PRO238 |
C | GLY239 |
C | ILE240 |
C | TYR374 |
C | HOH507 |
C | HOH551 |
D | ASP332 |
D | PPI501 |
site_id | AE1 |
Number of Residues | 21 |
Details | binding site for Di-peptide PLP D 502 and LYS D 46 |
Chain | Residue |
C | ASP332 |
C | PPI402 |
D | VAL44 |
D | VAL45 |
D | ALA47 |
D | ASP48 |
D | ALA49 |
D | TYR50 |
D | GLY70 |
D | ALA72 |
D | TRP96 |
D | KCX141 |
D | TRP179 |
D | HIS181 |
D | ASN221 |
D | SER222 |
D | ARG237 |
D | PRO238 |
D | GLY239 |
D | ILE240 |
D | TYR374 |
Functional Information from PROSITE/UniProt
site_id | PS00395 |
Number of Residues | 11 |
Details | ALANINE_RACEMASE Alanine racemase pyridoxal-phosphate attachment site. AVvKADAYGHG |
Chain | Residue | Details |
A | ALA43-GLY53 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor; specific for D-alanine => ECO:0000255|HAMAP-Rule:MF_01201 |
Chain | Residue | Details |
A | LYS46 | |
B | LYS46 | |
C | LYS46 | |
D | LYS46 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor; specific for L-alanine => ECO:0000255|HAMAP-Rule:MF_01201 |
Chain | Residue | Details |
A | TYR283 | |
B | TYR283 | |
C | TYR283 | |
D | TYR283 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01201 |
Chain | Residue | Details |
A | ARG148 | |
A | MET331 | |
B | ARG148 | |
B | MET331 | |
C | ARG148 | |
C | MET331 | |
D | ARG148 | |
D | MET331 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255|HAMAP-Rule:MF_01201 |
Chain | Residue | Details |
A | LYS46 | |
B | LYS46 | |
C | LYS46 | |
D | LYS46 |