5F7Z

Crystal structure of Double Mutant S12T and N87T of Adenosine/Methylthioadenosine Phosphorylase from Schistosoma mansoni in APO Form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006166	biological_process	purine ribonucleoside salvage
A	0009116	biological_process	nucleoside metabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
A	0019509	biological_process	L-methionine salvage from methylthioadenosine
B	0003824	molecular_function	catalytic activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006166	biological_process	purine ribonucleoside salvage
B	0009116	biological_process	nucleoside metabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
B	0019509	biological_process	L-methionine salvage from methylthioadenosine
C	0003824	molecular_function	catalytic activity
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006166	biological_process	purine ribonucleoside salvage
C	0009116	biological_process	nucleoside metabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
C	0019509	biological_process	L-methionine salvage from methylthioadenosine
D	0003824	molecular_function	catalytic activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006166	biological_process	purine ribonucleoside salvage
D	0009116	biological_process	nucleoside metabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
D	0019509	biological_process	L-methionine salvage from methylthioadenosine
E	0003824	molecular_function	catalytic activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006166	biological_process	purine ribonucleoside salvage
E	0009116	biological_process	nucleoside metabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
E	0019509	biological_process	L-methionine salvage from methylthioadenosine
F	0003824	molecular_function	catalytic activity
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006166	biological_process	purine ribonucleoside salvage
F	0009116	biological_process	nucleoside metabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0017061	molecular_function	S-methyl-5-thioadenosine phosphorylase activity
F	0019509	biological_process	L-methionine salvage from methylthioadenosine

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue PO4 A 301

Chain	Residue
A	GLY11
A	HOH470
A	HOH488
A	THR12
A	ARG54
A	HIS55
A	THR87
A	ALA88
A	THR207
A	HOH436
A	HOH453

---

site_id	AC2
Number of Residues	11
Details	binding site for residue PO4 B 301

Chain	Residue
B	GLY11
B	THR12
B	ARG54
B	HIS55
B	THR87
B	ALA88
B	THR207
B	HOH448
B	HOH454
B	HOH457
B	HOH461

---

site_id	AC3
Number of Residues	11
Details	binding site for residue PO4 C 301

Chain	Residue
C	GLY11
C	THR12
C	ARG54
C	HIS55
C	THR87
C	ALA88
C	THR207
C	HOH419
C	HOH460
C	HOH463
C	HOH481

---

site_id	AC4
Number of Residues	11
Details	binding site for residue PO4 D 301

Chain	Residue
D	GLY11
D	THR12
D	ARG54
D	HIS55
D	THR87
D	ALA88
D	THR207
D	HOH432
D	HOH454
D	HOH465
D	HOH495

---

site_id	AC5
Number of Residues	11
Details	binding site for residue PO4 E 301

Chain	Residue
E	GLY11
E	THR12
E	ARG54
E	HIS55
E	THR87
E	ALA88
E	THR207
E	HOH424
E	HOH461
E	HOH489
E	HOH498

---

site_id	AC6
Number of Residues	11
Details	binding site for residue PO4 F 301

Chain	Residue
F	GLY11
F	THR12
F	ARG54
F	HIS55
F	THR87
F	ALA88
F	THR207
F	HOH440
F	HOH473
F	HOH483
F	HOH496

---

Functional Information from PROSITE/UniProt

site_id	PS01240
Number of Residues	41
Details	PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LprhGkgHlIppseVnyrAn.VwAlkdlGcth.ILatTAcGSL

Chain	Residue	Details
A	LEU52-LEU92

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