5F76
Crystal structure of Mutant S12T of Adenosine/Methylthioadenosine Phosphorylase from Schistosoma mansoni in complex with Methylthioadenosine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| A | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| B | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0017061 | molecular_function | S-methyl-5-thioadenosine phosphorylase activity |
| C | 0019509 | biological_process | L-methionine salvage from methylthioadenosine |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue MTA A 301 |
| Chain | Residue |
| A | ALA88 |
| A | HOH416 |
| A | HOH470 |
| C | GLN289 |
| A | CYS89 |
| A | GLY90 |
| A | PHE187 |
| A | ASN205 |
| A | MET206 |
| A | ASP230 |
| A | ASP232 |
| A | SO4302 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | GLY11 |
| A | THR12 |
| A | ARG54 |
| A | HIS55 |
| A | ASN87 |
| A | ALA88 |
| A | ASN205 |
| A | THR207 |
| A | MTA301 |
| A | HOH525 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for residue MTA B 301 |
| Chain | Residue |
| A | GLN289 |
| B | ALA88 |
| B | CYS89 |
| B | GLY90 |
| B | PHE187 |
| B | ASN205 |
| B | MET206 |
| B | ASP230 |
| B | ASP232 |
| B | SO4302 |
| B | HOH442 |
| B | HOH455 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 B 302 |
| Chain | Residue |
| B | GLY11 |
| B | THR12 |
| B | ARG54 |
| B | HIS55 |
| B | ASN87 |
| B | ALA88 |
| B | ASN205 |
| B | THR207 |
| B | MTA301 |
| B | HOH506 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue MTA C 301 |
| Chain | Residue |
| B | HIS131 |
| B | GLN289 |
| C | THR12 |
| C | ALA88 |
| C | CYS89 |
| C | GLY90 |
| C | PHE187 |
| C | VAL204 |
| C | ASN205 |
| C | MET206 |
| C | THR229 |
| C | ASP230 |
| C | ASP232 |
| C | SO4302 |
| C | HOH488 |
| C | HOH498 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 C 302 |
| Chain | Residue |
| C | GLY11 |
| C | THR12 |
| C | ARG54 |
| C | HIS55 |
| C | ASN87 |
| C | ALA88 |
| C | ASN205 |
| C | THR207 |
| C | MTA301 |
| C | HOH451 |
Functional Information from PROSITE/UniProt
| site_id | PS01240 |
| Number of Residues | 41 |
| Details | PNP_MTAP_2 Purine and other phosphorylases family 2 signature. LprhGkgHlIppseVnyrAn.VwAlkdlGcth.ILatNAcGSL |
| Chain | Residue | Details |
| A | LEU52-LEU92 |
