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5F59

The crystal structure of MLL3 SET domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0042800molecular_functionhistone methyltransferase activity (H3-K4 specific)
A0044666cellular_componentMLL3/4 complex
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue ZN A 5001
ChainResidue
ACYS4851
ACYS4899
ACYS4901
ACYS4906

site_idAC2
Number of Residues16
Detailsbinding site for residue SAH A 5002
ChainResidue
ATYR4825
AARG4845
ATYR4846
AASN4848
AHIS4849
ATYR4886
APRO4898
ACYS4899
AHIS4900
AMET4910
AHOH5118
AILE4780
AGLN4781
AGLY4782
ALEU4783
AARG4822

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00190
ChainResidueDetails
ATYR4825

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASN4848
ACYS4851
ACYS4899
ACYS4901
ACYS4906

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PDB entries from 2024-10-30

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