5F2L
Tagatose-1,6-bisphosphate aldolase from Streptococcus pyogenes in complex with competitive inhibitor talitol-1,6-bisphosphate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005988 | biological_process | lactose metabolic process |
| A | 0009024 | molecular_function | tagatose-6-phosphate kinase activity |
| A | 0009025 | molecular_function | tagatose-bisphosphate aldolase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019512 | biological_process | lactose catabolic process via tagatose-6-phosphate |
| A | 0061595 | molecular_function | 6-deoxy-6-sulfofructose-1-phosphate aldolase activity |
| A | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
| A | 2001059 | biological_process | D-tagatose 6-phosphate catabolic process |
| B | 0005988 | biological_process | lactose metabolic process |
| B | 0009024 | molecular_function | tagatose-6-phosphate kinase activity |
| B | 0009025 | molecular_function | tagatose-bisphosphate aldolase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0019512 | biological_process | lactose catabolic process via tagatose-6-phosphate |
| B | 0061595 | molecular_function | 6-deoxy-6-sulfofructose-1-phosphate aldolase activity |
| B | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
| B | 2001059 | biological_process | D-tagatose 6-phosphate catabolic process |
| C | 0005988 | biological_process | lactose metabolic process |
| C | 0009024 | molecular_function | tagatose-6-phosphate kinase activity |
| C | 0009025 | molecular_function | tagatose-bisphosphate aldolase activity |
| C | 0016829 | molecular_function | lyase activity |
| C | 0019512 | biological_process | lactose catabolic process via tagatose-6-phosphate |
| C | 0061595 | molecular_function | 6-deoxy-6-sulfofructose-1-phosphate aldolase activity |
| C | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
| C | 2001059 | biological_process | D-tagatose 6-phosphate catabolic process |
| D | 0005988 | biological_process | lactose metabolic process |
| D | 0009024 | molecular_function | tagatose-6-phosphate kinase activity |
| D | 0009025 | molecular_function | tagatose-bisphosphate aldolase activity |
| D | 0016829 | molecular_function | lyase activity |
| D | 0019512 | biological_process | lactose catabolic process via tagatose-6-phosphate |
| D | 0061595 | molecular_function | 6-deoxy-6-sulfofructose-1-phosphate aldolase activity |
| D | 1902777 | biological_process | 6-sulfoquinovose(1-) catabolic process |
| D | 2001059 | biological_process | D-tagatose 6-phosphate catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | binding site for residue M2P A 3001 |
| Chain | Residue |
| A | ALA25 |
| A | GLU163 |
| A | LEU165 |
| A | LYS205 |
| A | SER249 |
| A | ALA250 |
| A | LEU275 |
| A | CYS276 |
| A | GLY277 |
| A | ARG278 |
| A | HOH3106 |
| A | ASP27 |
| A | HOH3111 |
| A | HOH3121 |
| A | HOH3150 |
| A | HOH3202 |
| A | HOH3208 |
| A | HOH3246 |
| A | GLN28 |
| A | ARG29 |
| A | GLY30 |
| A | ALA31 |
| A | THR94 |
| A | LYS125 |
| A | LEU127 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 3002 |
| Chain | Residue |
| A | GLU238 |
| A | THR241 |
| A | HOH3169 |
| B | GLU83 |
| B | GLU84 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 3003 |
| Chain | Residue |
| A | HOH3240 |
| A | HOH3316 |
| A | HOH3343 |
| A | HOH3357 |
| A | HOH3460 |
| B | HOH662 |
| B | HOH889 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 401 |
| Chain | Residue |
| C | ASP259 |
| C | HOH560 |
| C | HOH709 |
| D | ASP259 |
| D | HOH541 |
| D | HOH654 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 402 |
| Chain | Residue |
| A | HOH3325 |
| A | HOH3446 |
| A | HOH3458 |
| C | HOH737 |
| C | HOH761 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 403 |
| Chain | Residue |
| C | GLU84 |
| C | HOH523 |
| C | HOH532 |
| C | HOH564 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 404 |
| Chain | Residue |
| C | ARG29 |
| C | GLY30 |
| C | ALA31 |
| C | HOH754 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 401 |
| Chain | Residue |
| A | GLU83 |
| A | GLU84 |
| B | GLU238 |
| B | THR241 |
| B | HOH577 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 402 |
| Chain | Residue |
| A | HOH3344 |
| A | HOH3492 |
| B | HOH639 |
| B | HOH720 |
| B | HOH724 |
| B | HOH765 |
| B | HOH866 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 403 |
| Chain | Residue |
| B | ARG29 |
| B | GLY30 |
| B | ALA31 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue ACT D 401 |
| Chain | Residue |
| A | ARG198 |
| A | HOH3171 |
| B | ASP316 |
| D | LYS114 |
| D | GLU118 |
| D | HOH501 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue CL D 402 |
| Chain | Residue |
| D | ARG29 |
| D | GLY30 |
| D | ALA31 |
| D | HOH735 |
