5F2C
Thermostable aldehyde dehydrogenase from Pyrobaculum sp. 1860 crystallized in microgravity (complex with NADP+)
Replaces: 4NMKFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| E | 0000166 | molecular_function | nucleotide binding |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| F | 0000166 | molecular_function | nucleotide binding |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| G | 0000166 | molecular_function | nucleotide binding |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| H | 0000166 | molecular_function | nucleotide binding |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 33 |
| Details | binding site for residue NAP A 501 |
| Chain | Residue |
| A | ILE151 |
| A | GLY211 |
| A | GLY215 |
| A | PHE229 |
| A | THR230 |
| A | GLY231 |
| A | GLU232 |
| A | THR235 |
| A | GLU238 |
| A | LEU254 |
| A | GLY255 |
| A | THR152 |
| A | CYS287 |
| A | ASN332 |
| A | ARG334 |
| A | GLN335 |
| A | GLU382 |
| A | PHE384 |
| A | HOH603 |
| A | HOH618 |
| A | HOH635 |
| A | HOH669 |
| A | PRO153 |
| A | HOH708 |
| A | HOH720 |
| A | HOH741 |
| A | HOH889 |
| A | TRP154 |
| A | LYS178 |
| A | ALA180 |
| A | SER181 |
| A | ASP182 |
| A | PRO210 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | ARG237 |
| A | ASP407 |
| A | TYR408 |
| A | HOH878 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | binding site for residue NAP B 500 |
| Chain | Residue |
| B | ILE151 |
| B | THR152 |
| B | PRO153 |
| B | TRP154 |
| B | LYS178 |
| B | ALA180 |
| B | SER181 |
| B | GLY211 |
| B | GLY215 |
| B | PHE229 |
| B | GLY231 |
| B | GLU232 |
| B | THR235 |
| B | GLU238 |
| B | LEU254 |
| B | GLY255 |
| B | CYS287 |
| B | GLU382 |
| B | PHE384 |
| B | HOH605 |
| B | HOH643 |
| B | HOH666 |
| B | HOH723 |
| B | HOH847 |
| B | HOH880 |
| B | HOH894 |
| B | HOH899 |
| site_id | AC4 |
| Number of Residues | 32 |
| Details | binding site for residue NAP C 500 |
| Chain | Residue |
| C | ILE151 |
| C | THR152 |
| C | PRO153 |
| C | TRP154 |
| C | LYS178 |
| C | ALA180 |
| C | SER181 |
| C | ASP182 |
| C | GLY211 |
| C | GLY215 |
| C | PHE229 |
| C | THR230 |
| C | GLY231 |
| C | GLU232 |
| C | THR235 |
| C | LEU254 |
| C | GLY255 |
| C | CYS287 |
| C | ASN332 |
| C | ARG334 |
| C | GLN335 |
| C | GLU382 |
| C | PHE384 |
| C | HOH672 |
| C | HOH674 |
| C | HOH692 |
| C | HOH703 |
| C | HOH707 |
| C | HOH736 |
| C | HOH813 |
| C | HOH833 |
| C | HOH901 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | binding site for residue NAP D 500 |
| Chain | Residue |
| D | TRP154 |
| D | LYS178 |
| D | ALA180 |
| D | SER181 |
| D | PRO210 |
| D | GLY211 |
| D | GLY215 |
| D | PHE229 |
| D | THR230 |
| D | GLY231 |
| D | GLU232 |
| D | THR235 |
| D | GLY255 |
| D | CYS287 |
| D | ASN332 |
| D | ARG334 |
| D | GLN335 |
| D | GLU382 |
| D | PHE384 |
| D | HOH612 |
| D | HOH655 |
| D | HOH704 |
| D | HOH708 |
| D | HOH755 |
| D | ILE151 |
| D | THR152 |
| D | PRO153 |
| site_id | AC6 |
| Number of Residues | 28 |
| Details | binding site for residue NAP E 500 |
| Chain | Residue |
| E | ILE151 |
| E | THR152 |
| E | PRO153 |
| E | TRP154 |
| E | LYS178 |
| E | ALA180 |
| E | SER181 |
| E | PRO210 |
| E | GLY211 |
| E | GLY215 |
| E | PHE229 |
| E | GLY231 |
| E | GLU232 |
| E | THR235 |
| E | LEU254 |
| E | GLY255 |
| E | CYS287 |
| E | ASN332 |
| E | ARG334 |
| E | GLN335 |
| E | GLU382 |
| E | PHE384 |
| E | HOH601 |
| E | HOH622 |
| E | HOH623 |
| E | HOH643 |
| E | HOH785 |
| E | HOH819 |
| site_id | AC7 |
| Number of Residues | 29 |
| Details | binding site for residue NAP F 500 |
| Chain | Residue |
| F | ILE151 |
| F | THR152 |
| F | PRO153 |
| F | TRP154 |
| F | LYS178 |
| F | ALA180 |
| F | SER181 |
| F | PRO210 |
| F | GLY211 |
| F | GLY215 |
| F | PHE229 |
| F | GLY231 |
| F | GLU232 |
| F | THR235 |
| F | LEU254 |
| F | CYS287 |
| F | ASN332 |
| F | GLN335 |
| F | GLU382 |
| F | PHE384 |
| F | HOH613 |
| F | HOH615 |
| F | HOH619 |
| F | HOH638 |
| F | HOH762 |
| F | HOH763 |
| F | HOH772 |
| F | HOH861 |
| F | HOH871 |
| site_id | AC8 |
| Number of Residues | 34 |
| Details | binding site for residue NAP G 500 |
| Chain | Residue |
| G | ILE151 |
| G | THR152 |
| G | PRO153 |
| G | TRP154 |
| G | LYS178 |
| G | ALA180 |
| G | SER181 |
| G | PRO210 |
| G | GLY211 |
| G | GLY215 |
| G | GLU216 |
| G | PHE229 |
| G | THR230 |
| G | GLY231 |
| G | GLU232 |
| G | THR235 |
| G | LEU254 |
| G | GLY255 |
| G | CYS287 |
| G | ASN332 |
| G | ARG334 |
| G | GLN335 |
| G | GLU382 |
| G | PHE384 |
| G | HOH617 |
| G | HOH649 |
| G | HOH713 |
| G | HOH788 |
| G | HOH792 |
| G | HOH796 |
| G | HOH801 |
| G | HOH806 |
| G | HOH812 |
| G | HOH830 |
| site_id | AC9 |
| Number of Residues | 34 |
| Details | binding site for residue NAP H 500 |
| Chain | Residue |
| H | ILE151 |
| H | THR152 |
| H | PRO153 |
| H | TRP154 |
| H | LYS178 |
| H | ALA180 |
| H | SER181 |
| H | PRO210 |
| H | GLY211 |
| H | GLY215 |
| H | PHE229 |
| H | GLY231 |
| H | GLU232 |
| H | THR235 |
| H | LEU254 |
| H | GLY255 |
| H | CYS287 |
| H | ASN332 |
| H | ARG334 |
| H | GLN335 |
| H | GLU382 |
| H | PHE384 |
| H | HOH606 |
| H | HOH609 |
| H | HOH610 |
| H | HOH645 |
| H | HOH705 |
| H | HOH753 |
| H | HOH775 |
| H | HOH804 |
| H | HOH821 |
| H | HOH824 |
| H | HOH870 |
| H | HOH895 |
