Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 501 |
| Chain | Residue |
| A | HIS242 |
| A | TYR245 |
| A | HOH767 |
| A | HOH906 |
| A | HOH937 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 502 |
| Chain | Residue |
| A | HOH869 |
| A | HOH938 |
| A | VAL202 |
| A | THR205 |
| A | HOH675 |
| A | HOH799 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue DMS A 503 |
| Chain | Residue |
| A | ARG157 |
| A | ASN159 |
| A | GLU195 |
| A | HOH814 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | binding site for residue 5T7 A 504 |
| Chain | Residue |
| A | GLY72 |
| A | GLY74 |
| A | LEU91 |
| A | ASP93 |
| A | TYR132 |
| A | ILE171 |
| A | ASP289 |
| A | SER290 |
| A | GLY291 |
| A | THR292 |
| A | THR293 |
| A | ALA396 |
| A | ACT507 |
| A | HOH617 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue DMS A 505 |
| Chain | Residue |
| A | LYS279 |
| A | GLU280 |
| A | LYS300 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | binding site for residue GOL A 506 |
| Chain | Residue |
| A | HIS106 |
| A | PHE108 |
| A | SER166 |
| A | ASP167 |
| A | LYS168 |
| A | ILE171 |
| A | ASN172 |
| A | HOH604 |
| A | HOH604 |
| A | HOH605 |
| A | HOH680 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue ACT A 507 |
| Chain | Residue |
| A | LYS70 |
| A | SER71 |
| A | GLY72 |
| A | GLN73 |
| A | GLY74 |
| A | TYR75 |
| A | VAL231 |
| A | ARG368 |
| A | 5T7504 |
| A | HOH621 |
| A | HOH686 |
Functional Information from PROSITE/UniProt
| site_id | PS00141 |
| Number of Residues | 12 |
| Details | ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ILVDTGSSNFAV |
| Chain | Residue | Details |
| A | ILE90-VAL101 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10094","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"17425515","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19011241","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
