5EXM
FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl ~{N}-[4-[2-[(1~{S})-1-[[4-(aminomethyl)cyclohexyl]carbonylamino]-2-phenyl-ethyl]pyridin-4-yl]phenyl]carbamate
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 5ST A 301 |
| Chain | Residue |
| A | ARG39 |
| A | GLY193 |
| A | ASP194 |
| A | SER195 |
| A | THR213 |
| A | GLY218 |
| A | HOH472 |
| A | HOH502 |
| A | HOH510 |
| A | HIS40 |
| A | LEU41 |
| A | HIS57 |
| A | ILE151 |
| A | ASP189 |
| A | ALA190 |
| A | CYS191 |
| A | LYS192 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 302 |
| Chain | Residue |
| A | ARG170 |
| A | ARG170 |
| A | ARG184 |
| A | ARG184 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | VAL23 |
| A | ARG24 |
| A | GLY25 |
| A | GLU26 |
| A | TRP27 |
| A | ILE70 |
| A | LEU71 |
| A | LEU155 |
| A | HOH412 |
| A | HOH415 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | ASN49 |
| A | THR111 |
| A | VAL112 |
| A | GLY113 |
| A | TYR114 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | ARG24 |
| A | SER99 |
| A | GLY173 |
| A | LYS175 |
| A | HOH491 |
| A | HOH496 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | GLU98 |
| A | GLY216 |
| A | GLU217 |
| A | HOH401 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | HIS178 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 308 |
| Chain | Residue |
| A | SER99 |
| A | GLY100 |
| A | TYR101 |
| A | THR177 |
| A | LYS179 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 235 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"1998667","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25092234","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
