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5EXM

FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl ~{N}-[4-[2-[(1~{S})-1-[[4-(aminomethyl)cyclohexyl]carbonylamino]-2-phenyl-ethyl]pyridin-4-yl]phenyl]carbamate

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0006508biological_processproteolysis
Functional Information from PDB Data
site_idAC1
Number of Residues17
Detailsbinding site for residue 5ST A 301
ChainResidue
AARG39
AGLY193
AASP194
ASER195
ATHR213
AGLY218
AHOH472
AHOH502
AHOH510
AHIS40
ALEU41
AHIS57
AILE151
AASP189
AALA190
ACYS191
ALYS192

site_idAC2
Number of Residues4
Detailsbinding site for residue SO4 A 302
ChainResidue
AARG170
AARG170
AARG184
AARG184

site_idAC3
Number of Residues10
Detailsbinding site for residue SO4 A 303
ChainResidue
AVAL23
AARG24
AGLY25
AGLU26
ATRP27
AILE70
ALEU71
ALEU155
AHOH412
AHOH415

site_idAC4
Number of Residues5
Detailsbinding site for residue EDO A 304
ChainResidue
AASN49
ATHR111
AVAL112
AGLY113
ATYR114

site_idAC5
Number of Residues6
Detailsbinding site for residue EDO A 305
ChainResidue
AARG24
ASER99
AGLY173
ALYS175
AHOH491
AHOH496

site_idAC6
Number of Residues4
Detailsbinding site for residue EDO A 306
ChainResidue
AGLU98
AGLY216
AGLU217
AHOH401

site_idAC7
Number of Residues1
Detailsbinding site for residue EDO A 307
ChainResidue
AHIS178

site_idAC8
Number of Residues5
Detailsbinding site for residue EDO A 308
ChainResidue
ASER99
AGLY100
ATYR101
ATHR177
ALYS179

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLS
ChainResidueDetails
AASP189-SER200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING:
ChainResidueDetails
ALYS169

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:25092234
ChainResidueDetails
AASN72

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:1998667, ECO:0000269|PubMed:25092234
ChainResidueDetails
AGLY113

227111

PDB entries from 2024-11-06

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