5ETX
Crystal structure of HCV NS3/4A protease A156T variant in complex with 5172-Linear (MK-5172 linear analogue)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019062 | biological_process | virion attachment to host cell |
| A | 0019087 | biological_process | transformation of host cell by virus |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0044423 | cellular_component | virion component |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008236 | molecular_function | serine-type peptidase activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019062 | biological_process | virion attachment to host cell |
| B | 0019087 | biological_process | transformation of host cell by virus |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0044423 | cellular_component | virion component |
| B | 0046718 | biological_process | symbiont entry into host cell |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0006508 | biological_process | proteolysis |
| C | 0008233 | molecular_function | peptidase activity |
| C | 0008236 | molecular_function | serine-type peptidase activity |
| C | 0016020 | cellular_component | membrane |
| C | 0019062 | biological_process | virion attachment to host cell |
| C | 0019087 | biological_process | transformation of host cell by virus |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0044423 | cellular_component | virion component |
| C | 0046718 | biological_process | symbiont entry into host cell |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0006508 | biological_process | proteolysis |
| D | 0008233 | molecular_function | peptidase activity |
| D | 0008236 | molecular_function | serine-type peptidase activity |
| D | 0016020 | cellular_component | membrane |
| D | 0019062 | biological_process | virion attachment to host cell |
| D | 0019087 | biological_process | transformation of host cell by virus |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0044423 | cellular_component | virion component |
| D | 0046718 | biological_process | symbiont entry into host cell |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 1201 |
| Chain | Residue |
| A | CYS1097 |
| A | THR1098 |
| A | CYS1099 |
| A | CYS1145 |
| A | HIS1149 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue 5RS A 1202 |
| Chain | Residue |
| A | LEU1135 |
| A | LYS1136 |
| A | GLY1137 |
| A | SER1138 |
| A | SER1139 |
| A | PHE1154 |
| A | ARG1155 |
| A | THR1156 |
| A | ALA1157 |
| A | HOH1345 |
| C | THR1156 |
| C | ASP1168 |
| C | 5RS1202 |
| A | PHE1043 |
| A | HIS1057 |
| A | GLY1058 |
| A | ILE1132 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 1201 |
| Chain | Residue |
| B | CYS1097 |
| B | CYS1099 |
| B | CYS1145 |
| B | HIS1149 |
| site_id | AC4 |
| Number of Residues | 25 |
| Details | binding site for residue 5RS B 1202 |
| Chain | Residue |
| B | GLN1041 |
| B | PHE1043 |
| B | TYR1056 |
| B | HIS1057 |
| B | GLY1058 |
| B | VAL1078 |
| B | ASP1081 |
| B | ILE1132 |
| B | LEU1135 |
| B | LYS1136 |
| B | GLY1137 |
| B | SER1138 |
| B | SER1139 |
| B | PHE1154 |
| B | ARG1155 |
| B | THR1156 |
| B | ALA1157 |
| B | SER1159 |
| B | HOH1325 |
| B | HOH1336 |
| D | ASP1079 |
| D | ARG1155 |
| D | THR1156 |
| D | ASP1168 |
| D | 5RS1202 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue CL B 1203 |
| Chain | Residue |
| B | ARG1123 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 1201 |
| Chain | Residue |
| C | CYS1097 |
| C | CYS1099 |
| C | CYS1145 |
| C | HIS1149 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | binding site for residue 5RS C 1202 |
| Chain | Residue |
| A | ASP1079 |
| A | ARG1155 |
| A | THR1156 |
| A | ASP1168 |
| A | 5RS1202 |
| C | GLN1041 |
| C | PHE1043 |
| C | TYR1056 |
| C | HIS1057 |
| C | VAL1078 |
| C | ASP1081 |
| C | ILE1132 |
| C | LEU1135 |
| C | LYS1136 |
| C | GLY1137 |
| C | SER1138 |
| C | SER1139 |
| C | PHE1154 |
| C | ARG1155 |
| C | THR1156 |
| C | ALA1157 |
| C | SER1159 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 1201 |
| Chain | Residue |
| D | CYS1097 |
| D | THR1098 |
| D | CYS1099 |
| D | CYS1145 |
| D | HIS1149 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | binding site for residue 5RS D 1202 |
| Chain | Residue |
| D | ARG1155 |
| D | THR1156 |
| D | ALA1157 |
| B | THR1156 |
| B | ASP1168 |
| B | 5RS1202 |
| B | HOH1301 |
| B | HOH1325 |
| D | GLN1041 |
| D | PHE1043 |
| D | HIS1057 |
| D | GLY1058 |
| D | ILE1132 |
| D | LEU1135 |
| D | LYS1136 |
| D | GLY1137 |
| D | SER1138 |
| D | SER1139 |
| D | PHE1154 |
