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5ETV

S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.72 angstrom resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0003848molecular_function2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
A0005524molecular_functionATP binding
A0009396biological_processfolic acid-containing compound biosynthetic process
A0016301molecular_functionkinase activity
A0046654biological_processtetrahydrofolate biosynthetic process
A0046656biological_processfolic acid biosynthetic process
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue APC A 201
ChainResidue
ALEU71
ASER112
AHIS115
AARG117
AARG121
AMG203
AMG204
AHOH304
AHOH308
AHOH320
AHOH321
AARG83
AHOH324
AHOH326
AHOH330
AHOH334
AARG88
AARG92
AASP95
AASP97
AILE98
ALYS110
ALEU111

site_idAC2
Number of Residues14
Detailsbinding site for residue 5RZ A 202
ChainResidue
ATHR43
AALA44
APRO45
AVAL46
AGLY47
APHE54
AASN56
AARG88
AGLU104
AMET105
AARG121
APHE123
AHOH320
AHOH346

site_idAC3
Number of Residues6
Detailsbinding site for residue MG A 203
ChainResidue
AASP95
AASP97
AAPC201
AMG204
AHOH320
AHOH358

site_idAC4
Number of Residues6
Detailsbinding site for residue MG A 204
ChainResidue
AASP95
AASP97
AAPC201
AMG203
AHOH324
AHOH326

site_idAC5
Number of Residues6
Detailsbinding site for residue NO3 A 205
ChainResidue
AILE12
AARG83
AILE84
AARG85
AARG92
ATHR93

Functional Information from PROSITE/UniProt
site_idPS00794
Number of Residues12
DetailsHPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDVDIL
ChainResidueDetails
AARG88-LEU99

227933

PDB entries from 2024-11-27

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