5ETS
S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.95 angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | binding site for residue APC B 201 |
| Chain | Residue |
| B | LEU71 |
| B | SER112 |
| B | HIS115 |
| B | ARG117 |
| B | ARG121 |
| B | MG204 |
| B | MG205 |
| B | HOH306 |
| B | HOH309 |
| B | HOH315 |
| B | HOH323 |
| B | ARG83 |
| B | HOH325 |
| B | HOH326 |
| B | HOH327 |
| B | HOH328 |
| B | HOH341 |
| B | HOH357 |
| B | HOH360 |
| B | HOH365 |
| B | HOH369 |
| B | ARG85 |
| B | ARG92 |
| B | ASP95 |
| B | ASP97 |
| B | ILE98 |
| B | LYS110 |
| B | LEU111 |
| site_id | AC2 |
| Number of Residues | 16 |
| Details | binding site for residue 5RX B 202 |
| Chain | Residue |
| B | ASN11 |
| B | THR43 |
| B | ALA44 |
| B | PRO45 |
| B | VAL46 |
| B | TYR48 |
| B | GLN51 |
| B | PHE54 |
| B | ASN56 |
| B | GLY90 |
| B | PRO91 |
| B | ARG92 |
| B | ARG121 |
| B | PHE123 |
| B | HOH325 |
| B | HOH363 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue NA B 203 |
| Chain | Residue |
| A | NA203 |
| A | HOH356 |
| B | ASN27 |
| B | TYR29 |
| B | ILE32 |
| B | HOH320 |
| B | HOH372 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 204 |
| Chain | Residue |
| B | ASP95 |
| B | ASP97 |
| B | APC201 |
| B | MG205 |
| B | HOH325 |
| B | HOH365 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 205 |
| Chain | Residue |
| B | ASP95 |
| B | ASP97 |
| B | APC201 |
| B | MG204 |
| B | HOH326 |
| B | HOH357 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | binding site for residue NA B 206 |
| Chain | Residue |
| A | ASP107 |
| B | ASP107 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for residue APC A 201 |
| Chain | Residue |
| A | LEU71 |
| A | ARG83 |
| A | ARG92 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | LYS110 |
| A | LEU111 |
| A | SER112 |
| A | HIS115 |
| A | ARG117 |
| A | ARG121 |
| A | MG204 |
| A | MG205 |
| A | HOH302 |
| A | HOH313 |
| A | HOH315 |
| A | HOH317 |
| A | HOH323 |
| A | HOH331 |
| A | HOH332 |
| A | HOH346 |
| A | HOH353 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | binding site for residue 5RX A 202 |
| Chain | Residue |
| A | ARG92 |
| A | ARG121 |
| A | PHE123 |
| A | HOH323 |
| A | HOH348 |
| A | ASN11 |
| A | THR43 |
| A | ALA44 |
| A | PRO45 |
| A | VAL46 |
| A | TYR48 |
| A | GLN51 |
| A | PHE54 |
| A | ASN56 |
| A | GLY90 |
| A | PRO91 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 203 |
| Chain | Residue |
| A | ASN27 |
| A | TYR29 |
| A | ILE32 |
| A | HOH356 |
| B | NA203 |
| B | HOH320 |
| B | HOH372 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 204 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | APC201 |
| A | MG205 |
| A | HOH313 |
| A | HOH331 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 205 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | APC201 |
| A | MG204 |
| A | HOH323 |
| A | HOH346 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDVDIL |
| Chain | Residue | Details |
| B | ARG88-LEU99 |
