5ETQ
S. aureus 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase complexed with AMPCPP and inhibitor at 1.96 angstrom resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046656 | biological_process | folic acid biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | MG202 |
| A | APC203 |
| A | HOH342 |
| A | HOH355 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | APC203 |
| A | HOH310 |
| A | HOH327 |
| A | ASP95 |
| A | ASP97 |
| A | MG201 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue APC A 203 |
| Chain | Residue |
| A | LEU71 |
| A | ARG83 |
| A | ARG85 |
| A | ARG92 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | LYS110 |
| A | LEU111 |
| A | SER112 |
| A | HIS115 |
| A | ARG117 |
| A | ARG121 |
| A | MG201 |
| A | MG202 |
| A | YH2204 |
| A | HOH301 |
| A | HOH303 |
| A | HOH310 |
| A | HOH311 |
| A | HOH327 |
| A | HOH342 |
| A | HOH348 |
| A | HOH355 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue YH2 A 204 |
| Chain | Residue |
| A | ASN11 |
| A | THR43 |
| A | ALA44 |
| A | PRO45 |
| A | VAL46 |
| A | GLN51 |
| A | PHE54 |
| A | ASN56 |
| A | GLY90 |
| A | PRO91 |
| A | ARG92 |
| A | ARG121 |
| A | PHE123 |
| A | APC203 |
| A | HOH342 |
| A | HOH360 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 205 |
| Chain | Residue |
| A | ASN27 |
| A | TYR29 |
| A | ILE32 |
| A | HOH315 |
| A | HOH370 |
| B | NA205 |
| B | HOH358 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 206 |
| Chain | Residue |
| A | ASP107 |
| A | HOH333 |
| B | ASP107 |
| B | HOH311 |
| B | HOH332 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 201 |
| Chain | Residue |
| B | ASP95 |
| B | ASP97 |
| B | MG202 |
| B | APC203 |
| B | HOH309 |
| B | HOH341 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | ASP95 |
| B | ASP97 |
| B | MG201 |
| B | APC203 |
| B | HOH329 |
| B | HOH348 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | binding site for residue APC B 203 |
| Chain | Residue |
| B | LEU71 |
| B | ARG83 |
| B | ARG92 |
| B | ASP95 |
| B | ASP97 |
| B | ILE98 |
| B | LYS110 |
| B | LEU111 |
| B | SER112 |
| B | HIS115 |
| B | ARG117 |
| B | ARG121 |
| B | MG201 |
| B | MG202 |
| B | HOH301 |
| B | HOH309 |
| B | HOH313 |
| B | HOH329 |
| B | HOH341 |
| B | HOH348 |
| B | HOH353 |
| site_id | AD1 |
| Number of Residues | 15 |
| Details | binding site for residue YH2 B 204 |
| Chain | Residue |
| B | ALA44 |
| B | PRO45 |
| B | VAL46 |
| B | GLN51 |
| B | PHE54 |
| B | ASN56 |
| B | GLY90 |
| B | PRO91 |
| B | ARG92 |
| B | ARG121 |
| B | PHE123 |
| B | HOH329 |
| B | HOH347 |
| B | ASN11 |
| B | THR43 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue NA B 205 |
| Chain | Residue |
| A | NA205 |
| A | HOH315 |
| A | HOH370 |
| B | ASN27 |
| B | TYR29 |
| B | ILE32 |
| B | HOH358 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDVDIL |
| Chain | Residue | Details |
| A | ARG88-LEU99 |
