Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003848 | molecular_function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | binding site for residue APC A 201 |
| Chain | Residue |
| A | GLN74 |
| A | LEU111 |
| A | THR112 |
| A | HIS115 |
| A | TYR116 |
| A | ARG121 |
| A | GLN145 |
| A | HIS148 |
| A | CA204 |
| A | CA205 |
| A | 5RZ209 |
| A | ARG82 |
| A | HOH314 |
| A | HOH316 |
| A | HOH333 |
| A | HOH338 |
| A | HOH372 |
| A | HOH413 |
| A | HOH428 |
| A | HOH498 |
| A | HOH503 |
| A | ARG84 |
| A | TRP89 |
| A | ARG92 |
| A | ASP95 |
| A | ASP97 |
| A | ILE98 |
| A | ARG110 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 202 |
| Chain | Residue |
| A | GLY26 |
| A | ILE28 |
| A | SER31 |
| A | HOH361 |
| A | HOH396 |
| A | HOH434 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 203 |
| Chain | Residue |
| A | ASP49 |
| A | GLU87 |
| A | HOH405 |
| A | HOH448 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 204 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | APC201 |
| A | HOH356 |
| A | HOH471 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 205 |
| Chain | Residue |
| A | ASP95 |
| A | ASP97 |
| A | APC201 |
| A | HOH428 |
| A | HOH498 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 206 |
| Chain | Residue |
| A | ASP139 |
| A | HOH321 |
| A | HOH406 |
| A | HOH409 |
| A | HOH465 |
| A | HOH528 |
| A | HOH539 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 207 |
| Chain | Residue |
| A | MET0 |
| A | HOH327 |
| A | HOH350 |
| A | HOH454 |
| A | HOH509 |
| A | HOH521 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue NA A 208 |
| Chain | Residue |
| A | GLU30 |
| A | SER63 |
| A | HOH313 |
| A | HOH430 |
| A | HOH480 |
| A | HOH511 |
| A | HOH574 |
| site_id | AC9 |
| Number of Residues | 12 |
| Details | binding site for residue 5RZ A 209 |
| Chain | Residue |
| A | THR42 |
| A | PRO43 |
| A | PRO44 |
| A | LEU45 |
| A | TYR53 |
| A | ASN55 |
| A | TRP89 |
| A | ARG121 |
| A | PHE123 |
| A | APC201 |
| A | HOH356 |
| A | HOH407 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue CL A 210 |
| Chain | Residue |
| A | ARG82 |
| A | VAL83 |
| A | ARG92 |
| A | THR93 |
| A | HOH384 |
Functional Information from PROSITE/UniProt
| site_id | PS00794 |
| Number of Residues | 12 |
| Details | HPPK 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase signature. RwGPRtlDLDIM |
| Chain | Residue | Details |
| A | ARG88-MET99 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 151 |
| Chain | Residue | Details |
| A | ARG82 | electrostatic stabiliser, hydrogen bond donor |
| A | ARG92 | electrostatic stabiliser, hydrogen bond donor |
| A | ASP95 | metal ligand |
| A | ASP97 | metal ligand |
