5ET6

Human muscle fructose-1,6-bisphosphatase in inactive T-state in complex with AMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006000	biological_process	fructose metabolic process
A	0006094	biological_process	gluconeogenesis
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030018	cellular_component	Z disc
A	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
A	0042578	molecular_function	phosphoric ester hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0070161	cellular_component	anchoring junction
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006000	biological_process	fructose metabolic process
B	0006094	biological_process	gluconeogenesis
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0030018	cellular_component	Z disc
B	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
B	0042578	molecular_function	phosphoric ester hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0070161	cellular_component	anchoring junction
C	0003824	molecular_function	catalytic activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006000	biological_process	fructose metabolic process
C	0006094	biological_process	gluconeogenesis
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0030018	cellular_component	Z disc
C	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
C	0042578	molecular_function	phosphoric ester hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0070161	cellular_component	anchoring junction
D	0003824	molecular_function	catalytic activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0006000	biological_process	fructose metabolic process
D	0006094	biological_process	gluconeogenesis
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0030018	cellular_component	Z disc
D	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
D	0042578	molecular_function	phosphoric ester hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0070161	cellular_component	anchoring junction

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue AMP A 401

Chain	Residue
A	VAL17
A	LYS112
A	TYR113
A	VAL160
A	THR177
A	HOH520
A	HOH542
A	HOH601
A	HOH616
A	HOH638
A	LYS20
A	GLY21
A	ALA24
A	THR27
A	GLY28
A	GLU29
A	LEU30
A	THR31

---

site_id	AC2
Number of Residues	18
Details	binding site for residue AMP C 401

Chain	Residue
C	VAL17
C	LYS20
C	GLY21
C	ALA24
C	THR27
C	GLY28
C	GLU29
C	LEU30
C	THR31
C	LYS112
C	TYR113
C	ARG140
C	VAL160
C	THR177
C	HOH520
C	HOH580
C	HOH584
C	HOH637

---

site_id	AC3
Number of Residues	19
Details	binding site for residue AMP B 401

Chain	Residue
B	VAL17
B	LYS20
B	GLY21
B	ALA24
B	GLY26
B	THR27
B	GLY28
B	GLU29
B	LEU30
B	THR31
B	LYS112
B	TYR113
B	VAL160
B	THR177
B	HOH532
B	HOH543
B	HOH548
B	HOH561
B	HOH605

---

site_id	AC4
Number of Residues	19
Details	binding site for residue AMP D 401

Chain	Residue
D	VAL17
D	LYS20
D	GLY21
D	ALA24
D	GLY26
D	THR27
D	GLY28
D	GLU29
D	LEU30
D	THR31
D	LYS112
D	TYR113
D	VAL160
D	THR177
D	HOH518
D	HOH520
D	HOH547
D	HOH585
D	HOH587

---

Functional Information from PROSITE/UniProt

site_id	PS00124
Number of Residues	13
Details	FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPVA

Chain	Residue	Details
A	GLY273-ALA285

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"19626708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	28
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22120740","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	56
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Important for the conversion from active R-state to inactive T-state in the presence of AMP"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9Z1N1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---