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5ET6

Human muscle fructose-1,6-bisphosphatase in inactive T-state in complex with AMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005975biological_processcarbohydrate metabolic process
A0005986biological_processsucrose biosynthetic process
A0006000biological_processfructose metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006094biological_processgluconeogenesis
A0016787molecular_functionhydrolase activity
A0016791molecular_functionphosphatase activity
A0030018cellular_componentZ disc
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042578molecular_functionphosphoric ester hydrolase activity
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0070062cellular_componentextracellular exosome
A0070161cellular_componentanchoring junction
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005975biological_processcarbohydrate metabolic process
B0005986biological_processsucrose biosynthetic process
B0006000biological_processfructose metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006094biological_processgluconeogenesis
B0016787molecular_functionhydrolase activity
B0016791molecular_functionphosphatase activity
B0030018cellular_componentZ disc
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042578molecular_functionphosphoric ester hydrolase activity
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005975biological_processcarbohydrate metabolic process
C0005986biological_processsucrose biosynthetic process
C0006000biological_processfructose metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006094biological_processgluconeogenesis
C0016787molecular_functionhydrolase activity
C0016791molecular_functionphosphatase activity
C0030018cellular_componentZ disc
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042578molecular_functionphosphoric ester hydrolase activity
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0070062cellular_componentextracellular exosome
C0070161cellular_componentanchoring junction
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005975biological_processcarbohydrate metabolic process
D0005986biological_processsucrose biosynthetic process
D0006000biological_processfructose metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006094biological_processgluconeogenesis
D0016787molecular_functionhydrolase activity
D0016791molecular_functionphosphatase activity
D0030018cellular_componentZ disc
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042578molecular_functionphosphoric ester hydrolase activity
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
D0070062cellular_componentextracellular exosome
D0070161cellular_componentanchoring junction
Functional Information from PDB Data
site_idAC1
Number of Residues18
Detailsbinding site for residue AMP A 401
ChainResidue
AVAL17
ALYS112
ATYR113
AVAL160
ATHR177
AHOH520
AHOH542
AHOH601
AHOH616
AHOH638
ALYS20
AGLY21
AALA24
ATHR27
AGLY28
AGLU29
ALEU30
ATHR31

site_idAC2
Number of Residues18
Detailsbinding site for residue AMP C 401
ChainResidue
CVAL17
CLYS20
CGLY21
CALA24
CTHR27
CGLY28
CGLU29
CLEU30
CTHR31
CLYS112
CTYR113
CARG140
CVAL160
CTHR177
CHOH520
CHOH580
CHOH584
CHOH637

site_idAC3
Number of Residues19
Detailsbinding site for residue AMP B 401
ChainResidue
BVAL17
BLYS20
BGLY21
BALA24
BGLY26
BTHR27
BGLY28
BGLU29
BLEU30
BTHR31
BLYS112
BTYR113
BVAL160
BTHR177
BHOH532
BHOH543
BHOH548
BHOH561
BHOH605

site_idAC4
Number of Residues19
Detailsbinding site for residue AMP D 401
ChainResidue
DVAL17
DLYS20
DGLY21
DALA24
DGLY26
DTHR27
DGLY28
DGLU29
DLEU30
DTHR31
DLYS112
DTYR113
DVAL160
DTHR177
DHOH518
DHOH520
DHOH547
DHOH585
DHOH587

Functional Information from PROSITE/UniProt
site_idPS00124
Number of Residues13
DetailsFBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPVA
ChainResidueDetails
AGLY273-ALA285

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:22120740
ChainResidueDetails
AVAL17
BTHR27
BLYS112
BARG140
DVAL17
DTHR27
DLYS112
DARG140
ATHR27
ALYS112
AARG140
CVAL17
CTHR27
CLYS112
CARG140
BVAL17

site_idSWS_FT_FI2
Number of Residues40
DetailsBINDING:
ChainResidueDetails
AASP68
AGLU280
CASP68
CGLU97
CASP118
CLEU120
CASP121
CASN212
CTYR244
CTYR264
CLYS274
AGLU97
CGLU280
BASP68
BGLU97
BASP118
BLEU120
BASP121
BASN212
BTYR244
BTYR264
BLYS274
AASP118
BGLU280
DASP68
DGLU97
DASP118
DLEU120
DASP121
DASN212
DTYR244
DTYR264
DLYS274
ALEU120
DGLU280
AASP121
AASN212
ATYR244
ATYR264
ALYS274

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Important for the conversion from active R-state to inactive T-state in the presence of AMP
ChainResidueDetails
AGLN32
CGLN32
BGLN32
DGLN32

site_idSWS_FT_FI4
Number of Residues8
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q9Z1N1
ChainResidueDetails
ATYR215
ATYR218
CTYR215
CTYR218
BTYR215
BTYR218
DTYR215
DTYR218

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PDB entries from 2024-10-30

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