5ER7

Connexin-26 Bound to Calcium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005243	molecular_function	gap junction channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
A	0005886	cellular_component	plasma membrane
A	0005921	cellular_component	gap junction
A	0005922	cellular_component	connexin complex
A	0007154	biological_process	cell communication
A	0007267	biological_process	cell-cell signaling
A	0007605	biological_process	sensory perception of sound
A	0010644	biological_process	cell communication by electrical coupling
A	0016020	cellular_component	membrane
A	0016264	biological_process	gap junction assembly
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0070161	cellular_component	anchoring junction
A	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
A	1990349	biological_process	gap junction-mediated intercellular transport
B	0005243	molecular_function	gap junction channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
B	0005886	cellular_component	plasma membrane
B	0005921	cellular_component	gap junction
B	0005922	cellular_component	connexin complex
B	0007154	biological_process	cell communication
B	0007267	biological_process	cell-cell signaling
B	0007605	biological_process	sensory perception of sound
B	0010644	biological_process	cell communication by electrical coupling
B	0016020	cellular_component	membrane
B	0016264	biological_process	gap junction assembly
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0070161	cellular_component	anchoring junction
B	1903763	molecular_function	gap junction channel activity involved in cell communication by electrical coupling
B	1990349	biological_process	gap junction-mediated intercellular transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CA B 301

Chain	Residue
A	GLU42
B	GLY45
B	GLU47

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site_id	AC2
Number of Residues	3
Details	binding site for residue CA A 301

Chain	Residue
A	GLY45
A	GLU47
B	GLU42

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Functional Information from PROSITE/UniProt

site_id	PS00407
Number of Residues	14
Details	CONNEXINS_1 Connexins signature 1. CNTlQPGCknVCYD

Chain	Residue	Details
B	CYS53-ASP66

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site_id	PS00408
Number of Residues	17
Details	CONNEXINS_2 Connexins signature 2. Cnaw.PCpntVDCFVSRP

Chain	Residue	Details
B	CYS169-PRO185

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	158
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	128
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"description":"in other chain","evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ER7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26753910","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"5ER7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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