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5EQS

Crystal structure of a genotype 1a/3a chimeric HCV NS3/4A protease in complex with Asunaprevir

Functional Information from GO Data
ChainGOidnamespacecontents
A0003724molecular_functionRNA helicase activity
A0004252molecular_functionserine-type endopeptidase activity
A0006508biological_processproteolysis
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0008270molecular_functionzinc ion binding
A0016787molecular_functionhydrolase activity
A0019062biological_processvirion attachment to host cell
A0019087biological_processsymbiont-mediated transformation of host cell
A0033644cellular_componenthost cell membrane
A0039502biological_processsymbiont-mediated suppression of host type I interferon-mediated signaling pathway
A0039545biological_processsymbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
A0043657cellular_componenthost cell
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0052031biological_processsymbiont-mediated perturbation of host defense response
A0052170biological_processsymbiont-mediated suppression of host innate immune response
A0055036cellular_componentvirion membrane
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue 2R9 A 1201
ChainResidue
AARG997
ALEU1135
ALYS1136
AGLY1137
ASER1139
APHE1154
AARG1155
AALA1156
AALA1157
AGLN1168
AHOH1323
ATYR1006
AALA1007
AGLN1008
APHE1043
AHIS1057
AGLY1058
AVAL1078
AASP1081

site_idAC2
Number of Residues4
Detailsbinding site for residue ZN A 1202
ChainResidue
ACYS1097
ACYS1099
ACYS1145
AHIS1149

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PDB entries from 2026-08-19

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