5EQO

Human Angiogenin in complex with sulphate anions at an acidic solution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0001541	biological_process	ovarian follicle development
A	0001556	biological_process	oocyte maturation
A	0001666	biological_process	response to hypoxia
A	0001890	biological_process	placenta development
A	0001938	biological_process	positive regulation of endothelial cell proliferation
A	0002181	biological_process	cytoplasmic translation
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003779	molecular_function	actin binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0004540	molecular_function	RNA nuclease activity
A	0004549	molecular_function	tRNA-specific ribonuclease activity
A	0005102	molecular_function	signaling receptor binding
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005604	cellular_component	basement membrane
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005694	cellular_component	chromosome
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006898	biological_process	receptor-mediated endocytosis
A	0007154	biological_process	cell communication
A	0007165	biological_process	signal transduction
A	0008201	molecular_function	heparin binding
A	0009303	biological_process	rRNA transcription
A	0009725	biological_process	response to hormone
A	0010494	cellular_component	cytoplasmic stress granule
A	0015629	cellular_component	actin cytoskeleton
A	0016078	biological_process	tRNA decay
A	0016477	biological_process	cell migration
A	0016787	molecular_function	hydrolase activity
A	0017148	biological_process	negative regulation of translation
A	0019731	biological_process	antibacterial humoral response
A	0019843	molecular_function	rRNA binding
A	0023052	biological_process	signaling
A	0030041	biological_process	actin filament polymerization
A	0030139	cellular_component	endocytic vesicle
A	0030154	biological_process	cell differentiation
A	0030426	cellular_component	growth cone
A	0032055	biological_process	negative regulation of translation in response to stress
A	0032311	cellular_component	angiogenin-PRI complex
A	0033554	biological_process	cellular response to stress
A	0034063	biological_process	stress granule assembly
A	0036416	biological_process	tRNA stabilization
A	0042277	molecular_function	peptide binding
A	0042327	biological_process	positive regulation of phosphorylation
A	0042592	biological_process	homeostatic process
A	0042803	molecular_function	protein homodimerization activity
A	0043022	molecular_function	ribosome binding
A	0043025	cellular_component	neuronal cell body
A	0043066	biological_process	negative regulation of apoptotic process
A	0045087	biological_process	innate immune response
A	0048018	molecular_function	receptor ligand activity
A	0048662	biological_process	negative regulation of smooth muscle cell proliferation
A	0050714	biological_process	positive regulation of protein secretion
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	0071425	biological_process	hematopoietic stem cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue SO4 A 201

Chain	Residue
A	ARG32
A	ARG33

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 202

Chain	Residue
A	ARG24
A	HIS65
A	ARG66
A	HOH336

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 A 203

Chain	Residue
A	ASN49
A	LYS50
A	ARG51

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 204

Chain	Residue
A	TYR6
A	LYS50
A	LYS54
A	HOH320
A	HOH355

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 205

Chain	Residue
A	THR7
A	HIS8
A	THR11

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 A 206

Chain	Residue
A	SER37
A	HIS114
A	LEU115
A	ASP116
A	GLN117
A	SER118
A	ARG121

---

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdiNTF

Chain	Residue	Details
A	CYS39-PHE45

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Motif: {"description":"Nucleolar localization signal","evidences":[{"source":"PubMed","id":"7945327","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"11468363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38718836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9918722","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11468363","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38718836","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9918722","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"38718836","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"2866794","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 564

Chain	Residue	Details
A	HIS13	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
A	LYS40	electrostatic stabiliser
A	HIS114	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor

---