5EPT

Crystal Structure of S. cerevisiae TSA2 in the disulfide state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006457	biological_process	protein folding
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0034599	biological_process	cellular response to oxidative stress
A	0034605	biological_process	cellular response to heat
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0045454	biological_process	cell redox homeostasis
A	0050821	biological_process	protein stabilization
A	0051920	molecular_function	peroxiredoxin activity
A	0098869	biological_process	cellular oxidant detoxification
A	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006457	biological_process	protein folding
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0034599	biological_process	cellular response to oxidative stress
B	0034605	biological_process	cellular response to heat
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0045454	biological_process	cell redox homeostasis
B	0050821	biological_process	protein stabilization
B	0051920	molecular_function	peroxiredoxin activity
B	0098869	biological_process	cellular oxidant detoxification
B	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006457	biological_process	protein folding
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0034599	biological_process	cellular response to oxidative stress
C	0034605	biological_process	cellular response to heat
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0045454	biological_process	cell redox homeostasis
C	0050821	biological_process	protein stabilization
C	0051920	molecular_function	peroxiredoxin activity
C	0098869	biological_process	cellular oxidant detoxification
C	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006457	biological_process	protein folding
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0034599	biological_process	cellular response to oxidative stress
D	0034605	biological_process	cellular response to heat
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0045454	biological_process	cell redox homeostasis
D	0050821	biological_process	protein stabilization
D	0051920	molecular_function	peroxiredoxin activity
D	0098869	biological_process	cellular oxidant detoxification
D	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
E	0004601	molecular_function	peroxidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006457	biological_process	protein folding
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0034599	biological_process	cellular response to oxidative stress
E	0034605	biological_process	cellular response to heat
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0045454	biological_process	cell redox homeostasis
E	0050821	biological_process	protein stabilization
E	0051920	molecular_function	peroxiredoxin activity
E	0098869	biological_process	cellular oxidant detoxification
E	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
F	0004601	molecular_function	peroxidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006457	biological_process	protein folding
F	0006979	biological_process	response to oxidative stress
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0034599	biological_process	cellular response to oxidative stress
F	0034605	biological_process	cellular response to heat
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0045454	biological_process	cell redox homeostasis
F	0050821	biological_process	protein stabilization
F	0051920	molecular_function	peroxiredoxin activity
F	0098869	biological_process	cellular oxidant detoxification
F	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
G	0004601	molecular_function	peroxidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006457	biological_process	protein folding
G	0006979	biological_process	response to oxidative stress
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0034599	biological_process	cellular response to oxidative stress
G	0034605	biological_process	cellular response to heat
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0045454	biological_process	cell redox homeostasis
G	0050821	biological_process	protein stabilization
G	0051920	molecular_function	peroxiredoxin activity
G	0098869	biological_process	cellular oxidant detoxification
G	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
H	0004601	molecular_function	peroxidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006457	biological_process	protein folding
H	0006979	biological_process	response to oxidative stress
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0034599	biological_process	cellular response to oxidative stress
H	0034605	biological_process	cellular response to heat
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0045454	biological_process	cell redox homeostasis
H	0050821	biological_process	protein stabilization
H	0051920	molecular_function	peroxiredoxin activity
H	0098869	biological_process	cellular oxidant detoxification
H	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
I	0004601	molecular_function	peroxidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006457	biological_process	protein folding
I	0006979	biological_process	response to oxidative stress
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0034599	biological_process	cellular response to oxidative stress
I	0034605	biological_process	cellular response to heat
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0045454	biological_process	cell redox homeostasis
I	0050821	biological_process	protein stabilization
I	0051920	molecular_function	peroxiredoxin activity
I	0098869	biological_process	cellular oxidant detoxification
I	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity
J	0004601	molecular_function	peroxidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006457	biological_process	protein folding
J	0006979	biological_process	response to oxidative stress
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0034599	biological_process	cellular response to oxidative stress
J	0034605	biological_process	cellular response to heat
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0045454	biological_process	cell redox homeostasis
J	0050821	biological_process	protein stabilization
J	0051920	molecular_function	peroxiredoxin activity
J	0098869	biological_process	cellular oxidant detoxification
J	0140824	molecular_function	thioredoxin-dependent peroxiredoxin activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1580
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"26894543","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P34760","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"UniProtKB","id":"P34760","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---