5EPH

Crystal structure of extended-spectrum beta-lactamase BEL-1 in complex with Imipenem

Replaces:  4MXB

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0030655	biological_process	beta-lactam antibiotic catabolic process
A	0046677	biological_process	response to antibiotic
B	0008800	molecular_function	beta-lactamase activity
B	0016787	molecular_function	hydrolase activity
B	0017001	biological_process	antibiotic catabolic process
B	0030655	biological_process	beta-lactam antibiotic catabolic process
B	0046677	biological_process	response to antibiotic
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0030655	biological_process	beta-lactam antibiotic catabolic process
C	0046677	biological_process	response to antibiotic
D	0008800	molecular_function	beta-lactamase activity
D	0016787	molecular_function	hydrolase activity
D	0017001	biological_process	antibiotic catabolic process
D	0030655	biological_process	beta-lactam antibiotic catabolic process
D	0046677	biological_process	response to antibiotic

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 301

Chain	Residue
A	CYS61
A	SER62
A	THR63
A	ASN237

---

site_id	AC2
Number of Residues	3
Details	binding site for residue CL A 302

Chain	Residue
A	SER43
A	ASN45
B	LYS197

---

site_id	AC3
Number of Residues	11
Details	binding site for residue ID1 A 303

Chain	Residue
A	LYS65
A	TYR97
A	SER123
A	ASN125
A	GLU159
A	THR228
A	GLY229
A	SER230
A	HOH495
A	CYS61
A	SER62

---

site_id	AC4
Number of Residues	4
Details	binding site for residue CL B 301

Chain	Residue
B	CYS61
B	SER62
B	THR63
B	ASN237

---

site_id	AC5
Number of Residues	6
Details	binding site for residue MRD B 303

Chain	Residue
A	HIS283
B	ALA59
B	ASP169
B	HOH462
B	HOH466
B	HOH467

---

site_id	AC6
Number of Residues	5
Details	binding site for residue CL C 301

Chain	Residue
C	MET60
C	CYS61
C	SER62
C	THR63
C	ASN237

---

site_id	AC7
Number of Residues	4
Details	binding site for residue CL D 301

Chain	Residue
D	CYS61
D	SER62
D	THR63
D	ASN237

---

site_id	AC8
Number of Residues	12
Details	binding site for Di-peptide ID1 B 302 and SER B 62

Chain	Residue
B	MET60
B	CYS61
B	THR63
B	PHE64
B	LYS65
B	SER123
B	ASN125
B	THR228
B	GLY229
B	SER230
B	CL301
B	HOH421

---

site_id	AC9
Number of Residues	16
Details	binding site for Di-peptide ID1 C 302 and SER C 62

Chain	Residue
C	MET60
C	CYS61
C	THR63
C	PHE64
C	LYS65
C	TYR97
C	SER123
C	ASN125
C	GLU159
C	THR209
C	LYS227
C	THR228
C	GLY229
C	SER230
C	CL301
C	HOH429

---

site_id	AD1
Number of Residues	14
Details	binding site for Di-peptide ID1 D 302 and SER D 62

Chain	Residue
D	MET60
D	CYS61
D	THR63
D	PHE64
D	LYS65
D	TYR97
D	SER123
D	ASN125
D	THR228
D	GLY229
D	SER230
D	CL301
D	HOH470
D	HOH484

---

Functional Information from PROSITE/UniProt

site_id	PS00146
Number of Residues	16
Details	BETA_LACTAMASE_A Beta-lactamase class-A active site. FaMCSTfKlplAALVL

Chain	Residue	Details
A	PHE58-LEU73

---